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Proteins/UNIPROT:Q9UP95
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity)..
[Isoform 4]: No transporter activity..
Function from UniProtKB (Q9UP95), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
57 statements
57 statements · 6 reference databases · Subject: SLC12A4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
chlorine(.)+potassium atomchlorine(.)+potassium atom
Transported by SLC12A7 or SLC12A4 or SLC12A5 or SLC12A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05990CC BY 4.0Reference data
chlorine(.)+ammoniumchlorine(.)+ammonium
Transported by SLC12A7
4 names
Resolves to: SLC12A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06527CC BY 4.0Reference data
Transported by SLC12A5 or SLC12A6 or SLC12A4 or SLC12A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:72427CC BY 4.0Reference data