Proteins/UNIPROT:O15212

PFDN6

ProteinUNIPROT:O15212

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins..

Function from UniProtKB (O15212), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 4 reference databases · Subject: PFDN6 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ADAP1 covaries with PFDN6ProteinHetionet hetionet:covaries:10471-11033Inferred only
PFDN6 covaries with ARF3ProteinHetionet hetionet:covaries:10471-377Inferred only
FAM50A covaries with PFDN6ProteinHetionet hetionet:covaries:10471-9130Inferred only
PFDN6 covaries with FERMT3ProteinHetionet hetionet:covaries:10471-83706Inferred only
HOXC12 covaries with PFDN6ProteinHetionet hetionet:covaries:10471-3228Inferred only
PFDN6 covaries with SP7ProteinHetionet hetionet:covaries:10471-121340Inferred only
B4GALT2 interacts with PFDN6ProteinHetionet hetionet:interacts:10471-8704Inferred only
MAP3K3 interacts with PFDN6ProteinHetionet hetionet:interacts:10471-4215Inferred only
PFDN5 interacts with PFDN6ProteinHetionet hetionet:interacts:10471-5204Inferred only
PFDN6 interacts with THAP11ProteinHetionet hetionet:interacts:10471-57215Inferred only
UBC interacts with PFDN6ProteinHetionet hetionet:interacts:10471-7316Inferred only
PFDN6 participates in Cellular proteostasisPathwayWikiPathways WP4918Inferred only

Show the remaining 15

PFDN6 participates in Chaperonin-mediated protein foldingPathwayReactome R-HSA-390466Inferred only
PFDN6 participates in Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingPathwayReactome R-HSA-389958Inferred only
PFDN6 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PFDN6 participates in Prefoldin mediated transfer of substrate to CCT/TriCPathwayReactome R-HSA-389957Inferred only
PFDN6 participates in Protein foldingPathwayReactome R-HSA-391251Inferred only
PFDN6 regulates negative regulation of amyloid fibril formationBiological processgene ontology O15212|GO:1905907Inferred only
CDC42 decreases the expression of PFDN6ProteinHetionet hetionet:regulates:998-10471Inferred only
CPE decreases the expression of PFDN6ProteinHetionet hetionet:regulates:1363-10471Inferred only
KDM2B decreases the expression of PFDN6ProteinHetionet hetionet:regulates:84678-10471Inferred only
NMUR2 increases the expression of PFDN6ProteinHetionet hetionet:regulates:56923-10471Inferred only
POLD1 decreases the expression of PFDN6ProteinHetionet hetionet:regulates:5424-10471Inferred only
RPA2 increases the expression of PFDN6ProteinHetionet hetionet:regulates:6118-10471Inferred only
SLC6A8 increases the expression of PFDN6ProteinHetionet hetionet:regulates:6535-10471Inferred only
SPHK2 increases the expression of PFDN6ProteinHetionet hetionet:regulates:56848-10471Inferred only
TESK1 increases the expression of PFDN6ProteinHetionet hetionet:regulates:7016-10471Inferred only

Other names

5 names

Resolves to: PFDN6

Also called: HKE2Ke2PFD6Prefoldin subunit 6Protein Ke2

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