Proteins/UNIPROT:Q9Y597

KCTD3

ProteinUNIPROT:Q9Y597

Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics..

Function from UniProtKB (Q9Y597), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

genetic developmental and epileptic encephalopathy has a germline basis in KCTD3DiseaseGenCC HGNC:21305|MONDO:0100062Inferred only
neurodevelopmental disorder has a germline basis in KCTD3DiseaseGenCC HGNC:21305|MONDO:0700092Inferred only

Statements

26 statements

26 statements · 2 reference databases · Subject: KCTD3 · Sources: Hetionet, Reactome

Order

CFAP251 covaries with KCTD3ProteinHetionet hetionet:covaries:144406-51133Inferred only
KCTD3 covaries with HJVProteinHetionet hetionet:covaries:148738-51133Inferred only
MAP3K15 covaries with KCTD3ProteinHetionet hetionet:covaries:389840-51133Inferred only
ARRB1 interacts with KCTD3ProteinHetionet hetionet:interacts:408-51133Inferred only
COPS5 interacts with KCTD3ProteinHetionet hetionet:interacts:10987-51133Inferred only
CUL3 interacts with KCTD3ProteinHetionet hetionet:interacts:51133-8452Inferred only
KCTD3 interacts with DCUN1D1ProteinHetionet hetionet:interacts:51133-54165Inferred only
KCTD3 interacts with MMS19ProteinHetionet hetionet:interacts:51133-64210Inferred only
KCTD3 interacts with NAA38ProteinHetionet hetionet:interacts:51133-84316Inferred only
NEDD8 interacts with KCTD3ProteinHetionet hetionet:interacts:4738-51133Inferred only
UBC interacts with KCTD3ProteinHetionet hetionet:interacts:51133-7316Inferred only
KCTD3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only

Show the remaining 14

KCTD3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
KCTD3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KCTD3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
KCTD3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ACTB decreases the expression of KCTD3ProteinHetionet hetionet:regulates:60-51133Inferred only
ANXA5 decreases the expression of KCTD3ProteinHetionet hetionet:regulates:308-51133Inferred only
KCTD3 increases the expression of C2CD2ProteinHetionet hetionet:regulates:51133-25966Inferred only
KCTD3 increases the expression of CCL2ProteinHetionet hetionet:regulates:51133-6347Inferred only
KCTD3 increases the expression of CSRP1ProteinHetionet hetionet:regulates:51133-1465Inferred only
ID2 decreases the expression of KCTD3ProteinHetionet hetionet:regulates:3398-51133Inferred only
KDM2B decreases the expression of KCTD3ProteinHetionet hetionet:regulates:84678-51133Inferred only
NFKBIL1 decreases the expression of KCTD3ProteinHetionet hetionet:regulates:4795-51133Inferred only
KCTD3 increases the expression of PDHXProteinHetionet hetionet:regulates:51133-8050Inferred only
SENP6 decreases the expression of KCTD3ProteinHetionet hetionet:regulates:26054-51133Inferred only

Other names

2 names

Resolves to: KCTD3

Also called: BTB/POZ domain-containing protein KCTD3Renal carcinoma antigen NY-REN-45

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