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Proteins/UNIPROT:O60312
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer)..
Function from UniProtKB (O60312), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 7 reference databases · Subject: ATP10A · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
36 reactions
ATP+water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)ADP+proton+1,2-diacyl-sn-glycero-3-phosphocholine(1+)+phosphate(3-)
Transported by ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, mitochondrial matrix
Human-GEM MAR01583CC BY 4.0Reference data
7 names
Resolves to: ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR01594CC BY 4.0Reference data
ATP+water+phosphatidylethanolamineADP+proton+phosphatidylethanolamine+phosphate(3-)
Transported by ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, mitochondrial matrix
Human-GEM MAR01596CC BY 4.0Reference data
ATP+water+phosphatidyl-L-serineADP+proton+phosphate(3-)+phosphatidyl-L-serine
Transported by ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR01661CC BY 4.0Reference data
ATP+water+phosphatidyl-L-serineADP+proton+phosphate(3-)+phosphatidyl-L-serine
Transported by ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminablecytosol, mitochondrial matrix
Human-GEM MAR01664CC BY 4.0Reference data
MAM00516c+ATP+waterMAM00516e+ADP+proton+phosphate(3-)
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11572CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+ATP+watera 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+ADP+proton+phosphate(3-)
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11582CC BY 4.0Reference data
ATP+water+MAM03827cADP+proton+phosphate(3-)+MAM03827e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11587CC BY 4.0Reference data
ATP+water+MAM03805cADP+proton+phosphate(3-)+MAM03805e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11588CC BY 4.0Reference data
ATP+water+MAM03806cADP+proton+phosphate(3-)+MAM03806e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11589CC BY 4.0Reference data
ATP+water+MAM03808cADP+proton+phosphate(3-)+MAM03808e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11590CC BY 4.0Reference data
ATP+water+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineADP+proton+phosphate(3-)+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11591CC BY 4.0Reference data