Proteins/UNIPROT:O75173

ADAMTS4

ProteinUNIPROT:O75173

Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease..

Function from UniProtKB (O75173), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 4 reference databases · Subject: ADAMTS4 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

CDK1 covaries with ADAMTS4ProteinHetionet hetionet:covaries:9507-983Inferred only
G6PD covaries with ADAMTS4ProteinHetionet hetionet:covaries:2539-9507Inferred only
ACAN interacts with ADAMTS4ProteinHetionet hetionet:interacts:176-9507Inferred only
ADAMTS4 interacts with BCANProteinHetionet hetionet:interacts:63827-9507Inferred only
FN1 interacts with ADAMTS4ProteinHetionet hetionet:interacts:2335-9507Inferred only
FURIN interacts with ADAMTS4ProteinHetionet hetionet:interacts:5045-9507Inferred only
HP interacts with ADAMTS4ProteinHetionet hetionet:interacts:3240-9507Inferred only
MT2A interacts with ADAMTS4ProteinHetionet hetionet:interacts:4502-9507Inferred only
SERPINA1 interacts with ADAMTS4ProteinHetionet hetionet:interacts:5265-9507Inferred only
SERPINA3 interacts with ADAMTS4ProteinHetionet hetionet:interacts:12-9507Inferred only
ADAMTS4 interacts with SRPX2ProteinHetionet hetionet:interacts:27286-9507Inferred only
TIMP3 interacts with ADAMTS4ProteinHetionet hetionet:interacts:7078-9507Inferred only

Show the remaining 17

UBC interacts with ADAMTS4ProteinHetionet hetionet:interacts:7316-9507Inferred only
ADAMTS4 interacts with YTHDC1ProteinHetionet hetionet:interacts:91746-9507Inferred only
ZBTB16 interacts with ADAMTS4ProteinHetionet hetionet:interacts:7704-9507Inferred only
ADAMTS4 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
ADAMTS4 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
ADAMTS4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ADAMTS4 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
ADAMTS4 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ADAMTS4 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ADAMTS4 participates in Endochondral ossificationPathwayWikiPathways WP474Inferred only
ADAMTS4 participates in Endochondral ossification with skeletal dysplasiasPathwayWikiPathways WP4808Inferred only
ADAMTS4 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ADAMTS4 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ADAMTS4 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
ADAMTS4 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ADAMTS4 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ADAMTS4 requires the cofactor Zn(2+)CompoundUniProt O75173Inferred only

Other names

6 names

Resolves to: ADAMTS4

Also called: ADAM-TS 4ADAM-TS4ADAMTS-4ADMP-1Aggrecanase-1KIAA0688

← Every protein Find it in the graph →