Proteins/UNIPROT:Q07617

SPAG1

ProteinUNIPROT:Q07617

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity..

Function from UniProtKB (Q07617), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in SPAG1DiseaseGenCC HGNC:11212|MONDO:0016575Inferred only
primary ciliary dyskinesia 28 has a germline basis in SPAG1DiseaseGenCC HGNC:11212|MONDO:0014216Inferred only

Statements

17 statements

17 statements · 2 reference databases · Subject: SPAG1 · Sources: Hetionet, WikiPathways

Order

CENPP covaries with SPAG1ProteinHetionet hetionet:covaries:401541-6674Inferred only
SPAG1 covaries with IL12RB1ProteinHetionet hetionet:covaries:3594-6674Inferred only
NUP214 covaries with SPAG1ProteinHetionet hetionet:covaries:6674-8021Inferred only
SPAG1 covaries with SEC31BProteinHetionet hetionet:covaries:25956-6674Inferred only
SPAG1 covaries with VCANProteinHetionet hetionet:covaries:1462-6674Inferred only
ESR1 interacts with SPAG1ProteinHetionet hetionet:interacts:2099-6674Inferred only
GNB1 interacts with SPAG1ProteinHetionet hetionet:interacts:2782-6674Inferred only
PRKCA interacts with SPAG1ProteinHetionet hetionet:interacts:5578-6674Inferred only
SPAG1 interacts with UBCProteinHetionet hetionet:interacts:6674-7316Inferred only
SPAG1 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
SPAG1 participates in Effect of dasatinib on the BCR ABL signaling pathwayPathwayWikiPathways WP5493Inferred only
BTG2 increases the expression of SPAG1ProteinHetionet hetionet:regulates:7832-6674Inferred only

Show the remaining 5

ERCC1 increases the expression of SPAG1ProteinHetionet hetionet:regulates:2067-6674Inferred only
GNAS increases the expression of SPAG1ProteinHetionet hetionet:regulates:2778-6674Inferred only
KTN1 increases the expression of SPAG1ProteinHetionet hetionet:regulates:3895-6674Inferred only
POLR2K decreases the expression of SPAG1ProteinHetionet hetionet:regulates:5440-6674Inferred only
RYK increases the expression of SPAG1ProteinHetionet hetionet:regulates:6259-6674Inferred only

Other names

2 names

Resolves to: SPAG1

Also called: HSD-3.8Infertility-related sperm protein Spag-1

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