Pathway
Formation of Incision Complex in GG-NER
After the XPC complex and the UV-DDB complex bind damaged DNA, a basal transcription factor TFIIH is recruited to the nucleotide excision repair (NER) site. DNA helicases ERCC2 (XPD) and ERCC3 (XPB) are subunits of the TFIIH complex. ERCC2 unwinds the DNA around the damage in concert with the ATPase activity of ERCC3, creating an open bubble. Simultaneously, the presence of the damage is verified by XPA. The recruitment of XPA is partially regulated by PARP1 and/or PARP2.
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Two DNA endonucleases, ERCC5 (XPG) and the complex of ERCC1 and ERCC4 (XPF), are recruited to the open bubble structure to form the incision complex that will excise the damaged oligonucleotide from the affected DNA strand. The RPA heterotrimer coats the undamaged DNA strand, thus protecting it from the endonucleolytic attack (De Laat et al. 1998).
REACT:R-HSA-5696395Reactome
What the reference databases state
Statements
43 statements
43 statements · 1 reference database · Subject: Formation of Incision Complex in GG-NER · Sources: Reactome
- CCNH participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- CDK7 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- CETN2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- CHD1L participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- CUL4A participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- CUL4B participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- DDB1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- DDB2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- ERCC1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- ERCC2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- ERCC3 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- ERCC4 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
Show the remaining 31
- ERCC5 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- GTF2H1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- GTF2H2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- GTF2H3 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- GTF2H4 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- GTF2H5 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- MNAT1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- PARP1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- PARP2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- PIAS1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- PIAS3 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RAD23A participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RAD23B participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RBX1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RNF111 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RPA1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RPA2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RPA3 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- RPS27A participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- SUMO1 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- SUMO2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- SUMO3 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBA52 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBB participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBC participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBE2I participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBE2N participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- UBE2V2 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- USP45 participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- XPA participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only
- XPC participates in Formation of Incision Complex in GG-NERProteinReactome R-HSA-5696395Inferred only