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Proteins/UNIPROT:Q96CM8
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation..
Function from UniProtKB (Q96CM8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
92 statements
92 statements · 7 reference databases · Subject: ACSF2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
21 reactions
MAM00279c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01219c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or
1 name
Resolves to: ACSF2
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01065CC BY 4.0Reference data
MAM01219c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01176c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01066CC BY 4.0Reference data
MAM01176c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01055c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 11 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01067CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00310c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01068CC BY 4.0Reference data
MAM00310c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00259c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01069CC BY 4.0Reference data
MAM00259c+ATP+CHEBI:1146900+proton+2water+NAD(+)+dioxygenMAM01210c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01070CC BY 4.0Reference data
MAM00345m+ATP+CHEBI:1146900+2water+NAD(+)MAM00287m+AMP+2proton+NADH(2-)+diphosphate(3-)+propionyl-CoA
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-mitochondrial matrix
Human-GEM MAR06432CC BY 4.0Reference data
MAM00287m+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01226m+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06433CC BY 4.0Reference data
MAM01186m+ATP+CHEBI:1146900+2water+dioxygenMAM01096m+CHEBI:15351+AMP+proton+hydrogen peroxide+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06435CC BY 4.0Reference data
MAM01096m+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00766m+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)+propionyl-CoA
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-mitochondrial matrix
Human-GEM MAR06436CC BY 4.0Reference data
MAM00289m+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01228m+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06448CC BY 4.0Reference data
MAM01228m+ATP+CHEBI:1146900+2water+NAD(+)MAM01188m+AMP+2proton+NADH(2-)+diphosphate(3-)+propionyl-CoA
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-mitochondrial matrix
Human-GEM MAR06450CC BY 4.0Reference data