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Proteins/UNIPROT:P0CG08
Voltage-gated channel that enables the transfer of anions such as iodide, chloride, bromide and fluoride which may function in counter-ion conductance and participates in Golgi acidification. Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). Essential for maintaining the acidic luminal pH of the Golgi apparatus in neurons, which is important for preserving Golgi structural integrity (By similarity). This integrity supports proper axonal transport and synaptic maintenance in cerebellar inhibitory neurons, including Purkinje and basket cells (By similarity). Additionally, Golgi acidification facilitates the activation of SREBP2, thereby ensuring sufficient cholesterol biosynthesis necessary for normal neuronal morphology and function (By similarity)..
Function from UniProtKB (P0CG08), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 2 reference databases · Subject: GPHRB · Sources: Rhea, WikiPathways
4 reactions
7 names
Resolves to: GPHRB
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLCN1 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 or AQP6 or SLC5A8 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:75383CC BY 4.0Reference data