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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8NHS3

MFSD8

Protein·UNIPROT:Q8NHS3Major facilitator superfamily domain-containing protein 8

Open in the graph

Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions..

Function from UniProtKB (Q8NHS3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

macular dystrophy with central cone involvement has a germline basis in MFSD8DiseaseGenCC HGNC:28486|MONDO:0014515Inferred only
neuronal ceroid lipofuscinosis has a germline basis in MFSD8DiseaseGenCC HGNC:28486|MONDO:0016295Inferred only
neuronal ceroid lipofuscinosis 7 has a germline basis in MFSD8DiseaseGenCC HGNC:28486|MONDO:0012588Inferred only

Statements

3 statements

3 statements · 2 reference databases · Subject: MFSD8 · Sources: Hetionet, Rhea

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MFSD8 covaries with ZNF140ProteinHetionet hetionet:covaries:256471-7699Inferred only
chloride is transported by MFSD8CompoundRhea RHEA:29823Inferred only
iodide is transported by MFSD8CompoundRhea RHEA:66324Inferred only

Reactions

3 reactions

chloridechloride
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data

Other names

3 names

Resolves to: MFSD8

Also called: Ceroid-lipofuscinosis neuronal protein 7CLN7Major facilitator superfamily domain-containing protein 8

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⇌

Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives

Reaction pageReversibleBalanced

Rhea RHEA:66324CC BY 4.0Reference data

CHEBI:17051CHEBI:17051

Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLDN8 or CLDN17 or MFSD8 or CLCC1 or CLIC4

Reaction pageRight to leftBalanced

Rhea RHEA:76159CC BY 4.0Reference data