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Proteins/UNIPROT:P35523
Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization. Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide..
Function from UniProtKB (P35523), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
10 statements
10 statements · 3 reference databases · Subject: CLCN1 · Sources: Hetionet, Reactome, Rhea
5 reactions
3 names
Resolves to: CLCN1
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLDN17 or SLC1A5 or SLC26A7 or CLIC4
Reaction pageDirection not assertedBalanced
Rhea RHEA:75347CC BY 4.0Reference data