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Proteins/UNIPROT:P57739
Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (By similarity). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (By similarity). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (By similarity)..
Function from UniProtKB (P57739), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 4 · transported by
4 compounds
4 compounds.
0 reported routes4 assembled routes
32 statements
32 statements · 7 reference databases · Subject: CLDN2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways
9 reactions
2 names
Resolves to: CLDN2
Transported by AQP7B or AQP12B or AQP7 or AQP9 or AQP8 or AQP1 or MIP or AQP2 or AQP5 or AQP4 or CLDN15 or CLDN2 and 5 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29667CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by SLC35F4 or SLC22A2 or SLC22A1 or SLC22A3 or SLC35G4 or CHRNA7 or CLDN2 or SLC25A48 or SLC35F2 or SLC35F3 or SLC35F5 or FLVCR2 and 2 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:32751CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
Transported by AQP8 or CLDN15 or CLDN2 or CLDN10 or RHAG or RHBG or RHCG
Reaction pageLeft to rightBalanced
Rhea RHEA:74391CC BY 4.0Reference data
Transported by KCNK1 or KCNQ3 or KCNQ2 or KCNK2 or CNGA1 or CLDN15 or CLDN2 or KCNK10 or CLDN10 or CNGB1 or CNGA2 or CNGA3 and 8 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78547CC BY 4.0Reference data
Transported by KCNK1 or CNGA1 or GRIA1 or TRPC1 or CLDN15 or CLDN2 or ASIC1 or CLDN10 or CNGB1 or CNGA2 or CNGA3 or ASIC2 and 7 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78551CC BY 4.0Reference data