(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Activation of adipic acid for Formation of Adipoyl Carnitine

Catalysed by BAAT, ACOT6cytosolOne of 4 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Production of 3-Hydroxyoctadecenoylcarnitinec

Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by BAAT, ACOT6, CYP4F2, CYP4F3 and 2 morecytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

Catalysed by BAAT, ACOT6, CRAT, CROTcytosol, peroxisomeOne of 3 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

Catalysed by BAAT, ACOT6, ACAA1, HSD17B4 and 2 morecytosol, peroxisome

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Production of Hexadecanedioylcarnitine

Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

1. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
2. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate

Catalysed by AGPAT4, LPIN1

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase

Catalysed by BAAT, ACOT6cytosolOne of 2 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. fatty-acid-CoA ligase

Catalysed by BAAT, ACOT6, SLC27A2cytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

Catalysed by MOGAT1cytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

Catalysed by LPCAT2, LPCAT1cytosol

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by LPCAT4cytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (undecylic acid)

Catalysed by BAAT, ACOT6, ACSM4, ACSM1 and 4 morecytosolOne of 3 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate

Catalysed by BAAT, ACOT6, ALOX5, ALOX15 and 1 morecytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Catalysed by LPCAT1, PNPLA8

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate

Catalysed by AGPAT4, LPIN1

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate

Catalysed by BAAT, ACOT6, ALOX12Bcytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + O2 = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H2O2
2. (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)

Catalysed by ACOX1, DECR2

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

Catalysed by BAAT, ACOT6, ACADM, ECHS1 and 2 morecytosol, mitochondrial matrix

1. Beta Oxidation of Long Chain Fatty Acid
2. Acyl-CoA:cholesterol O-acyltransferase

Catalysed by ECI2, ACADL, HADHA, ECI1 and 6 moremitochondrial matrix, endoplasmic reticulumOne of 2 routes

1. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
2. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate

Catalysed by AGPAT4, CDS2, CDS1

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

Catalysed by BAAT, ACOT6, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrix

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by GLYATL1B, GLYATL1cytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O

Catalysed by BAAT, ACOT6, PTGS2cytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O

Catalysed by BAAT, ACOT6, PTGS2cytosol

1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrixOne of 2 routes

1. Beta Oxidation of Long Chain Fatty Acid
2. Acyl-CoA:cholesterol O-acyltransferase
3. Steryl-ester acylhydrolase