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Proteins/UNIPROT:Q9NUI1
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid..
Function from UniProtKB (Q9NUI1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 6 reference databases · Subject: DECR2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
MAM00422x+NADP(3-)MAM00423x+proton+NADPH(4-)
Catalysed by DECR2
Reaction pageReversibleBalancedEC 1.3.1.34peroxisome
Human-GEM MAR01297CC BY 4.0Reference data
MAM00682x+proton+NADPH(4-)NADP(3-)+MAM03034x
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.34peroxisome
5 names
Resolves to: DECR2
MAM00072x+proton+NADPH(4-)MAM00089x+NADP(3-)
Catalysed by DECR2
Reaction pageReversibleBalancedEC 1.3.1.34peroxisome
Human-GEM MAR03471CC BY 4.0Reference data
MAM00678x+proton+NADPH(4-)NADP(3-)+(3E)-decenoyl-CoA
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.124peroxisome
Human-GEM MAR04974CC BY 4.0Reference data
proton+NADPH(4-)+(2E,4Z,7Z)-decatrienoyl-CoANADP(3-)+MAM03205x
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.124peroxisome
Human-GEM MAR05017CC BY 4.0Reference data
proton+NADPH(4-)+MAM03653xNADP(3-)+MAM03221x
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.124peroxisome
Human-GEM MAR05293CC BY 4.0Reference data
proton+NADPH(4-)+(2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoANADP(3-)+MAM03220x
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.124peroxisome
Human-GEM MAR05321CC BY 4.0Reference data
proton+NADPH(4-)+MAM03557xNADP(3-)+MAM03210x
Catalysed by DECR2
Reaction pageLeft to rightBalancedEC 1.3.1.124peroxisome
Human-GEM MAR05405CC BY 4.0Reference data
MAM00287m+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01226m+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06433CC BY 4.0Reference data
MAM01186m+ATP+CHEBI:1146900+2water+dioxygenMAM01096m+CHEBI:15351+AMP+proton+hydrogen peroxide+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06435CC BY 4.0Reference data
MAM00289m+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01228m+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06448CC BY 4.0Reference data
MAM01188m+ATP+CHEBI:1146900+2water+dioxygenMAM01097m+CHEBI:15351+AMP+proton+hydrogen peroxide+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or DECR1 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT and 16 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-mitochondrial matrix
Human-GEM MAR06451CC BY 4.0Reference data