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Proteins/UNIPROT:Q92903
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs. Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis. Positively regulates the differentiation and development of adipocytes (By similarity)..
Function from UniProtKB (Q92903), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
52 statements
52 statements · 9 reference databases · Subject: CDS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
12 reactions
CHEBI:17677+proton+phosphatidic acidMAM01427c+diphosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.41cytosol
Human-GEM MAR00121CC BY 4.0Reference data
CHEBI:17677+proton+phosphatidic acidMAM01427m+diphosphate(3-)
Catalysed by CDS2
8 names
Resolves to: CDS1
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.41mitochondrial matrix
Human-GEM MAR00122CC BY 4.0Reference data
CHEBI:17677+proton+phosphatidic acidMAM01426m+diphosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.41mitochondrial matrix
Human-GEM MAR00581CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphate+CTP+hydrona CDP-1,2-diacyl-sn-glycerol+diphosphate(3-)
Catalysed by CDS2 or CDS1 or TAMM41
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16229CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+CTP+hydron1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45648CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+CTP+hydron1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45652CC BY 4.0Reference data
1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate+CTP+hydron1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45656CC BY 4.0Reference data
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+CTP+hydron1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45660CC BY 4.0Reference data
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate+CTP+hydron1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45664CC BY 4.0Reference data
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate+CTP+hydron1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45668CC BY 4.0Reference data
1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+CTP+hydron1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45672CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+CTP+hydron1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:45676CC BY 4.0Reference data