2-oxo-3-sulfanylpropanoate

Three steps

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (2S)-2-aminobutanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 7 routes

• nonadecanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Activation of dodecanedioic acid

  Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrixOne of 4 routes

• decanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of Sebacoylcarnitine

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 4 routes

• octanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of Suberylcarnitine

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrixOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 2-iminobutanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by MPST, TST, AGXT2, RIDAcytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrix

• (13Z)-eicosenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 2-aminoprop-2-enoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by MPST, TST, SRRcytosol

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by GOT2, GOT1, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by GOT2, GOT1, NAGS, CRAT and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by GOT2, GOT1, NAGS, ACAA1 and 3 morecytosol, mitochondrial matrix, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of Hexadecanedioylcarnitine

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 2 routes

• pristanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. fatty-acid-CoA ligase

  Catalysed by GOT2, GOT1, NAGS, SLC27A2cytosol, mitochondrial matrixOne of 2 routes

• undecanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by GOT2, GOT1, NAGS, ACSM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• ursodeoxycholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 3 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX2 and 1 more

• (5Z)-tetradecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, ACADM and 3 morecytosol, mitochondrial matrix

• a methyl thioetherReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)

  Catalysed by MPST, SUMF1, TMT1B, TMT1A

• N-tetradecanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-docosanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-hexacosanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• an N(2)-acyl-L-glutamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 3 morecytosol, extracellular space

• (7Z)-hexadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 4 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, PTGES, MGST3 and 4 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• thromboxane B2Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• an S-substituted glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by MPST, TSTD1, GSTT4, GSTA4 and 21 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GSTA1 and 2 more

• taurochenodeoxycholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. solute carrier organic anion transporter (GSH)

  Catalysed by GOT2, GOT1, SLCO1A2, SLC7A9 and 1 morecytosol, extracellular spaceOne of 3 routes

• thiamine(1+) diphosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by MPST, TST, PDHA1, PDHB and 2 morecytosol, mitochondrial matrix