3,3',5-triiodo-L-thyronine

Three steps

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, UGT1A9 and 3 moreextracellular space, cytosol

• 3-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1One of 2 routes

• serotonin O-sulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4extracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-thyronineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by DIO1, DIO3, DIO2cytosolOne of 2 routes

• thyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1

• 3'-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1

• 3,3',5'-triiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by SLCO1A2, SLCO1B3, PON1, PON2 and 1 moreextracellular space, cytosol

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by DIO1, DIO3, DIO2, SLC26A4 and 1 morecytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Peroxidase

  Catalysed by DIO1, DIO3, DIO2, SLC26A4 and 1 morecytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosolOne of 3 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by SLCO1A2, SLCO1B3, FAAHextracellular space, cytosol

• imidazole-4-acetaldehydeReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLCO1A2, SLCO1B3, AOC2, AOC1 and 1 moreextracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. Folate Transport by Oats

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, extracellular spaceOne of 4 routes

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by SLCO1A2, SLCO1B3, AOC2, AOC1 and 3 moreextracellular space, cytosolOne of 2 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosolOne of 3 routes

• CHEBI:28918Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLCO1A2, SLCO1B3, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• iron(2+)Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by SLCO1A2, SLCO1B3, CYBRD1extracellular space, cytosol

• K(+)Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLCO1A2, SLCO1B3, CARS1extracellular space, cytosol

• hydrogenselenideReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by DIO1, DIO3, AIFM1, PYROXD1 and 1 more

• hydrogen sulfideReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLCO1A2, SLCO1B3, CTHextracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• acetateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. transport of acetylcholine and GSH (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 3 routes

• oxalateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 6 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-Formylglutathione hydrolase

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 5 moreextracellular space, cytosolOne of 3 routes

• citric acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by DIO1, DIO3, D2HGDH, CSmitochondrial matrixOne of 2 routes

• maleateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by DIO1, DIO3, DIO2, SLC26A4cytosol, extracellular spaceOne of 4 routes

• glutarateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. solute carrier organic anion transporter (glycocholate)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 12 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by DIO1, DIO3, D2HGDH, GOT2mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. aryl sulfotransferase (PAPS)
  2. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SULT1A3, SULT1A4, SULT1A1, SULT1A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• pentanoateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• methylarsonateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 9 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of GSH and triiodothyronine (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 8 moreextracellular space, cytosolOne of 4 routes