D-ribose 1-phosphate

Three steps

• enol-oxaloacetateReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. (R)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by PNP, NQO2, SDHB, SDHAcytosolOne of 2 routes

• urateReach from here →
  1. xanthosine:orthophosphate ribosyltransferase
  2. xanthosine:orthophosphate ribosyltransferase
  3. xanthine:NAD+ oxidoreductase

  Catalysed by PNP, XDHcytosolOne of 6 routes

• fumaric acidReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by PNP, NQO2, SDHBcytosol

• CHEBI:18381Reach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. ATP:inosine 5'-phosphotransferase
  3. IMP 1,2-hydrolase (decyclizing)

  Catalysed by PNP, ATICcytosol, mitochondrial matrix

• a quinolReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

  Catalysed by PNP, NQO2, CYC1, UQCRFS1cytosol, outer side of the membraneOne of 13 routes

• orotateReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by PNP, NQO2, DHODHcytosol

• 2-deoxy-alpha-D-ribose 1-phosphateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. dIMP + inosine = 2'-deoxyinosine + IMP
  3. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

  Catalysed by PNP, NT5C2cytosolOne of 2 routes

• XMPReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. ATP:D-ribose-5-phosphate diphosphotransferase
  3. XMP:pyrophosphate phosphoribosyltransferase

  Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 4 routes

• nicotinate beta-D-ribonucleotideReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. ATP:D-ribose-5-phosphate diphosphotransferase
  3. nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

  Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes

• orotidine 5'-phosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. ATP:D-ribose-5-phosphate diphosphotransferase
  3. orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

  Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosol

• dCMPReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. Adenosine Kinase
  3. UMP/CMP kinase (dCDP)

  Catalysed by PNPcytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. ATP:inosine 5'-phosphotransferase
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by PNP, ADSS2, ADSS1cytosol, mitochondrial matrixOne of 2 routes

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. transketolase (D-xylulose-5-phosphate)
  3. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

  Catalysed by PGM2, TKT, TKTL1, TKTL2 and 2 morecytosol

• beta-D-fructose 6-phosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. transketolase (D-xylulose-5-phosphate)
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by PGM2, TKT, TKTL1, TKTL2 and 1 morecytosol

• dihydroxyacetone phosphateReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by PNP, NQO2, GPD2cytosol

• dGMPReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. dIMP + inosine = 2'-deoxyinosine + IMP
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by PNP, NT5C2cytosolOne of 7 routes

• D-xylulose 5-phosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. D-ribose-5-phosphate aldose-ketose-isomerase
  3. D-ribulose 5-phosphate = D-xylulose 5-phosphate

  Catalysed by PGM2, RPIA, RPEL1, RPEcytosol, endoplasmic reticulum

• (2R)-3-phosphoglycerateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
  3. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by PNP, LACC1, PGM2L1cytosol

• aldehydo-D-ribose 5-phosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. D-ribose-5-phosphate aldose-ketose-isomerase
  3. aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate

  Catalysed by PGM2, RPIAcytosol, endoplasmic reticulum

• 5-phospho-beta-D-ribosylamineReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. ATP:D-ribose-5-phosphate diphosphotransferase
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by PNP, NQO2, SQORcytosol

• dIMPReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. dIMP + inosine = 2'-deoxyinosine + IMP
  3. dIMP + inosine = 2'-deoxyinosine + IMP

  Catalysed by PNP, NT5C2cytosolOne of 2 routes

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by PNP, NQO2, PRODH2cytosol

• alpha-D-ribose 1,5-bisphosphateReach from here →
  1. D-Ribose 1,5-phosphomutase
  2. ATP:D-ribose-5-phosphate diphosphotransferase
  3. 5-phospho-alpha-D-ribose 1-diphosphate + H2O = alpha-D-ribose 1,5-bisphosphate + phosphate + H(+)

  Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes

• alpha-NAD(+)Reach from here →
  1. purine nucleoside phosphorylase (nicotinamide)
  2. purine nucleoside phosphorylase (nicotinamide)
  3. alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)

  Catalysed by PNP, MACROD2, ADPRH, MACROD1 and 2 morecytosol

• D-ribose 5-phosphateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
  3. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate

  Catalysed by PNP, LACC1, PGM2cytosol