What the reference databases state

GenCC submitters' classifications

9 rows

Arts syndrome has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0010533Inferred only
Charcot-Marie-Tooth disease X-linked recessive 5 has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0010699Inferred only
hearing loss, X-linked 1 has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0010577Inferred only
mild phosphoribosylpyrophosphate synthetase superactivity has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0018463Inferred only
phosphoribosylpyrophosphate synthetase superactivity has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0010395Inferred only
PRPS1 deficiency disorder has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0100061Inferred only
severe phosphoribosylpyrophosphate synthetase superactivity has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0018464Inferred only
X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0018495Inferred only
X-linked nonsyndromic hearing loss has a germline basis in PRPS1DiseaseGenCC HGNC:9462|MONDO:0019586Inferred only

Statements

31 statements

31 statements · 7 reference databases · Subject: PRPS1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

PRPS1 is expressed in islet of LangerhansAnatomyBgee ENSG00000147224Inferred only
PRPS1 is expressed in sural nerveAnatomyBgee ENSG00000147224Inferred only
PRPS1 interacts with GORASP2ProteinHetionet hetionet:interacts:26003-5631Inferred only
PRPS1 interacts with PCLAFProteinHetionet hetionet:interacts:5631-9768Inferred only
PRPS1 interacts with PRPSAP1ProteinHetionet hetionet:interacts:5631-5635Inferred only
PRPS1 interacts with SMURF1ProteinHetionet hetionet:interacts:5631-57154Inferred only
PRPS1 interacts with SPG21ProteinHetionet hetionet:interacts:51324-5631Inferred only
PRPS1 interacts with SUMO4ProteinHetionet hetionet:interacts:387082-5631Inferred only
PRPS1 interacts with UBCProteinHetionet hetionet:interacts:5631-7316Inferred only
PRPS1 participates in 5-Phosphoribose 1-diphosphate biosynthesisPathwayReactome R-HSA-73843Inferred only
PRPS1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PRPS1 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only

Show the remaining 19

PRPS1 participates in Nucleotide metabolismPathwayWikiPathways WP404Inferred only
PRPS1 participates in Pentose phosphate pathwayPathwayReactome R-HSA-71336Inferred only
PRPS1 participates in PGK1 PKM2 KHKC KHKA acting as protein kinasesPathwayWikiPathways WP5433Inferred only
PRPS1 participates in Purine metabolismPathwayWikiPathways WP4792Inferred only
PRPS1 participates in Purine metabolism and related disordersPathwayWikiPathways WP4224Inferred only
CDC25A decreases the expression of PRPS1ProteinHetionet hetionet:regulates:993-5631Inferred only
PRPS1 decreases the expression of CNPY3ProteinHetionet hetionet:regulates:5631-10695Inferred only
PRPS1 decreases the expression of CREB1ProteinHetionet hetionet:regulates:5631-1385Inferred only
CTNNAL1 decreases the expression of PRPS1ProteinHetionet hetionet:regulates:8727-5631Inferred only
PRPS1 decreases the expression of GDF15ProteinHetionet hetionet:regulates:5631-9518Inferred only
IL6ST decreases the expression of PRPS1ProteinHetionet hetionet:regulates:3572-5631Inferred only
OVOL2 decreases the expression of PRPS1ProteinHetionet hetionet:regulates:58495-5631Inferred only
PSPH decreases the expression of PRPS1ProteinHetionet hetionet:regulates:5723-5631Inferred only
RBM34 decreases the expression of PRPS1ProteinHetionet hetionet:regulates:23029-5631Inferred only
PRPS1 increases the expression of SLC1A4ProteinHetionet hetionet:regulates:5631-6509Inferred only
PRPS1 decreases the expression of TMSB15AProteinHetionet hetionet:regulates:5631-11013Inferred only
PRPS1 requires the cofactor magnesium(2+)CompoundUniProt P60891Inferred only
CHEBI:17797 is a substrate of PRPS1CompoundHuman-GEM MAR04052Inferred only
D-ribose 5-phosphate is a substrate of PRPS1CompoundRhea RHEA:15609Inferred only

Reactions

2 reactions

ATP+CHEBI:17797AMP+proton+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by PRPS2 or PRPS1 or PRPS1L1
Reaction pageLeft to rightBalancedEC 2.7.6.1cytosol
Human-GEM MAR04052CC BY 4.0Reference data
D-ribose 5-phosphate+ATP(4-)5-phospho-alpha-D-ribose 1-diphosphate+AMP+

Other names

3 names

Resolves to: PRPS1

Also called: Phosphoribosyl pyrophosphate synthetase subunit IPPRibPPRS-I