tetra-mu3-sulfido-tetrairon(2+)

Three steps

• butanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Production of Glutaryl Carnitine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. phytanate-CoA ligase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 11 moremitochondrial matrix, cytosolOne of 15 routes

• prostaglandin H2Reach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrixOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrixOne of 2 routes

• D-alanineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

• (R)-S-lactoylglutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 4-guanidinobutanoateReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• L-dopaReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. lipoyl synthase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• L-histidineReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-ornithineReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, extracellular space, cytosol

• S-formylglutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• guanidinoacetateReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• sphing-4-enineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 8 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• D-threonineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• spermidineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 3 routes

• N-sulfo-D-glucosamineReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• L-dopaquinoneReach from here →
  1. lipoyl synthase
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• L-threonineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-saccharopineReach from here →
  1. lipoyl synthase
  2. transport of lysine and methionine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• L-kynurenineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrixOne of 5 routes

• beta-alanineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• leukotriene C4Reach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 8 moremitochondrial matrixOne of 2 routes

• biliverdin IXalphaReach from here →
  1. lipoyl synthase
  2. Ferrochelatase, Mitochondrial
  3. Heme Oxygenase 1

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 2 routes

• taurocyamineReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• L-glutamate 5-semialdehydeReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. lipoyl synthase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• 3-hydroxy-L-kynurenineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix

• L,L-cystathionineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. lipoyl synthase
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. lipoyl synthase
  2. transport of lysine and methionine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosol, peroxisome

• carbamoyl phosphateReach from here →
  1. lipoyl synthase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• adenosine 5'-phosphosulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. ATP:sulfate adenylyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 4 routes

• N,N-dimethylglycineReach from here →
  1. lipoyl synthase
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• glutathione disulfideReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 23 routes

• L-tyrosineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes