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Proteins/UNIPROT:Q9NXE4
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity)..
Function from UniProtKB (Q9NXE4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
25 statements
25 statements · 6 reference databases · Subject: SMPD4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt
4 reactions
water+a sphingomyelinan N-acylsphing-4-enine+proton+CHEBI:18132
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12cytosol
Human-GEM MAR00795CC BY 4.0Reference data
6 names
Resolves to: SMPD4
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12lysosome
Human-GEM MAR00797CC BY 4.0Reference data
water+MAM02931cproton+CHEBI:18132+sphing-4-enine
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalancedEC 3.1.4.12cytosol
Human-GEM MAR08246CC BY 4.0Reference data
a sphingomyelin+waterphosphocholine+an N-acylsphing-4-enine+hydron
Catalysed by SMPD2 or SMPD1 or ENPP7 or SMPD4 or SMPD3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19253CC BY 4.0Reference data