a cholesterol ester

Three steps

• 7alpha-hydroxycholest-4-en-3-oneReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Cholest-5-Ene-3Beta, 7Alpha-Diol:NAD+ 3-Oxidoreductase Bile Acid Biosynthesis

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreendoplasmic reticulumOne of 5 routes

• dodecanoateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
  3. H2O[c] + N-dodecanoylsphing-4-enine[c] = lauric acid[c] + sphingosine[c]

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 morecytosolOne of 2 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 morecytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 moreOne of 3 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 moreOne of 3 routes

• beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more

• 11-cis-retinyl esterReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• 13-cis-retinyl esterReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• 9-cis-retinyl esterReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

  Catalysed by CEL, LIPA, ALOX5lysosome

• 1D-myo-inositol 1,4,5-trisphosphateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 15 moreinner side of the membrane, outer side of the membrane

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 3 routes

• a long-chain alcohol wax esterReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more

• octanoateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-octanoylsphing-4-enine + H2O = octanoate + sphing-4-enine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more

• elaidic acidReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. H2O[g] + N-(9Z-octadecenoyl)-sphing-4-enine[g] = elaidate[g] + sphingosine[g]

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 moreGolgi apparatus

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• 17alpha-hydroxypregnenoloneReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. cytochrome P450 (pregnenolone)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 morecytosolOne of 3 routes

• phosphocholineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 5 more

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 1 more

• an N-acylsphinganineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 5 more

• (15Z)-tetracosenoateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 4 more

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
  3. sterol esterase (Cholesteryl Arachidonate)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 4 morelysosome

• fatty acidReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CEL, LIPAlysosome, cytosolOne of 34 routes

• 7alpha,25-dihydroxycholesterolReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. cytochrome P450 (25-hydroxycholesterol)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreendoplasmic reticulumOne of 2 routes

• (24S)-7alpha-dihydroxycholesterolReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. 7alpha-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-7alpha-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 4 routes

• D-glucoseReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by CEL, LIPA, DGAT1, PNPLA4 and 2 morelysosome

• 16-hydroxyhexadecanoateReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by CEL, LIPA, CYP4F2, CYP4F3lysosome, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 7 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. long-chain-fatty-acid-CoA ligase (linoleate)

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 6 morelysosome, cytosolOne of 5 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by CEL, LIPA, SLC27A2, ACSL3 and 6 morelysosome

• octadecanoyl-CoAReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 5 morelysosome, cytosolOne of 6 routes

• 7,8-dihydrofolateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by CEL, LIPA, ALOX15B, ALOX15lysosome, cytosol

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 4 more

• (R)-2-hydroxyoctadecanoateReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by CEL, LIPA, FA2Hlysosome

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylsphing-4-enine 1-phosphateReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 4 more

• sphing-4-enineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CES1, LIPN, NCEH1, LDAH and 6 moreGolgi apparatusOne of 14 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate

  Catalysed by CES1, LIPN, NCEH1, LDAH and 4 moreinner side of the membrane, outer side of the membrane

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

  Catalysed by CES1, LIPN, NCEH1, LDAH and 5 moreinner side of the membrane, outer side of the membrane

• an acyl-CoAReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CES1, LIPN, NCEH1, LDAH and 6 moreGolgi apparatusOne of 2 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  2. Steryl-ester acylhydrolase
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by CEL, LIPAlysosome, cytosol

• Fe(II)-heme aReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• pregn-5-ene-3,20-dioneReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 morecytosolOne of 2 routes

• 4-methylpentan-1-olReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. aldose reductase (isocaproic-aldehyde)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 3 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more

• a 1-acyl-sn-glycerolReach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by CES1, LIPN, NCEH1, LDAH and 1 more

• a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine

  Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more