CHEBI:16284

Three steps

• octanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 1 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 7 morecytosolOne of 15 routes

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• sphing-4-enineReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 1 morecytosol

• spermidineReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 4 routes

• L-tryptophanReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• L-alanineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 21 routes

• L-asparagineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 3 routes

• IMPReach from here →
  1. ATP:dADP phosphotransferase
  2. dADP to dATP conversion
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by NME4, NME6, NME1, NME2 and 2 morecytosol, mitochondrial matrix

• L-phenylalanineReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• D-ribulose 5-phosphateReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. D-Ribulose-5-phosphate 3-epimerase

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol

• L,L-cystathionineReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 1 morecytosol, mitochondrial matrix

• alpha-D-glucose 6-phosphateReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

  Catalysed by HK1, HK2, HKDC1, GNPDA1 and 2 morecytosol

• (2R)-2-phosphoglycerateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by NME4, NME6, NME1, NME2 and 7 morecytosol

• an acyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• 7,8-dihydroneopterin 3'-triphosphateReach from here →
  1. nucleoside-diphosphate kinase (dADP)
  2. dTTP + H2O = thymidine + triphosphate + H(+)
  3. 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosol, endoplasmic reticulumOne of 3 routes

• D-glucosamine 6-phosphateReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1cytosolOne of 2 routes

• 5-amino-2-oxopentanoateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• deoxycholoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosolOne of 4 routes

• thiamine diphosphateReach from here →
  1. Antiport of thiamine-diphosphate and dATP
  2. ATP:thiamine-diphosphate phosphotransferase
  3. thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)

  Catalysed by SLC25A19, TPK1, THTPAmitochondrial matrix, cytosolOne of 2 routes

• D-glyceraldehyde 3-phosphateReach from here →
  1. dATP:D-fructose 6-phosphotransferase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosolOne of 3 routes

• decanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 6 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 11 routes

• D-glucose 6-phosphateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  3. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 1 morecytosol, endoplasmic reticulumOne of 4 routes

• dUTPReach from here →
  1. ATP:dADP phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol, mitochondrial matrixOne of 5 routes

• a ribonucleoside 5'-triphosphateReach from here →
  1. ATP:dADP phosphotransferase
  2. cytidine/uridine monophosphate kinase (dADP)
  3. 2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)

  Catalysed by NME4, NME6, NME1, NME2 and 3 morecytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 2 morecytosol

• CHEBI:63544Reach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 9 routes

• 2-acetamido-2-deoxy-D-glucopyranose 1-phosphateReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. phosphoglucomutase (N-acetylglucosamine-6-phosphate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 1 morecytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 3 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. ATP:dADP phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by NME4, NME6, NME1, NME2 and 4 morecytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. dATP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by HK1, HK2, HKDC1, GNPNAT1 and 8 morecytosolOne of 7 routes