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thiamine diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

7 compounds within 3 steps: 1 in 1, 1 in 2, 5 in 3

Does it reach a compound?

One step

thiamine triphosphateReach from here →
1. thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
Catalysed by THTPAOne of 2 routes

Two steps

thiamine(1+) diphosphateReach from here →
1. thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
2. Thiamin-triphosphate phosphohydrolase
Catalysed by THTPAcytosol

Three steps

CHEBI:16284Reach from here →
Catalysed by THTPA, SLC25A19cytosol, mitochondrial matrixOne of 2 routes
2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
Catalysed by THTPA

cytosol, mitochondrial matrix

3-methyl-1-hydroxybutylthiamine diphosphateReach from here →

thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
Thiamin-triphosphate phosphohydrolase
branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

Catalysed by THTPA, BCKDHA, BCKDHBcytosol, mitochondrial matrix

2-methyl-1-hydroxypropylthiamine diphosphateReach from here →

thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
Thiamin-triphosphate phosphohydrolase
branched chain keto acid dehydrogenase E1 (3-methyl-2-oxobutyrate)

Catalysed by THTPA, BCKDHA, BCKDHBcytosol, mitochondrial matrix

2-(1-hydroxyethyl)thiamine diphosphateReach from here →

thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)
Thiamin-triphosphate phosphohydrolase
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by THTPA, PDHA1, PDHB, PDHA2cytosol, mitochondrial matrix