1,2-diacyl-sn-glycero-3-phosphocholine(1+)

Three steps

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty acylamide amidohydrolase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space, cytosol

• CHEBI:27540Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosolOne of 6 routes

• dodecanalReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[r] + lauric acid[r] + NADH[r] = H2O[r] + NAD+[r] + dodecanal[r]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular spaceOne of 3 routes

• CHEBI:28701Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, peroxisomeOne of 7 routes

• a carboxylateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PTDSS1, BCHEcytosol

• hydrogenselenideReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by PTDSS1, CHDH, SCLYcytosol

• acetateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetylcholine aectylhydrolase

  Catalysed by PTDSS1, CHAT, BCHE, ACHEcytosolOne of 3 routes

• formic acidReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, SLC26A4cytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by PTDSS1, SLC5A7cytosol, extracellular spaceOne of 2 routes

• (24S)-hydroxycholesterolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• a fatty aldehydeReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• a sterol esterReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, LCATGolgi apparatus

• 12-hydroxydodecanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. alkane 1-monooxygenase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)

  Catalysed by SGMS1, SGMS2, CHPT1, CEPT1Golgi apparatus, endoplasmic reticulum, cytosol

• a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase

  Catalysed by SGMS1, SGMS2, CHPT1, CEPT1Golgi apparatus, endoplasmic reticulum, cytosol

• 25-hydroxycholesterolReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by PTDSS1, CHDH, CH25HcytosolOne of 4 routes

• all-trans-4-oxoretinolReach from here →
  1. Lecithin Retinol Acyltransferase
  2. carboxylesterase (retinyl-ester)
  3. cytochrome P450 (retinol)

  Catalysed by LRAT, CES2, RBP4, LIPF and 18 morecytosol

• 13-cis-retinolReach from here →
  1. Lecithin Retinol Acyltransferase
  2. carboxylesterase (retinyl-ester)
  3. retinol binding protein (retinol)

  Catalysed by LRAT, CES2, RBP4, LIPF and 19 morecytosolOne of 3 routes

• N-octanoylsphing-4-enineReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• a 1,3-diacylglycerolReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, DGAT1, MOGAT2 and 5 moreGolgi apparatus, cytosolOne of 5 routes

• a 1,2-diacylglycerolReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, DGAT1, MOGAT2 and 7 moreGolgi apparatus, cytosolOne of 6 routes

• (24R)-hydroxycholesterolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• taurineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by PTDSS1, CHDH, RETSATcytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space, cytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO2cytosol

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, extracellular space

• 16-hydroxyhexadecanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular spaceOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO3cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by SGMS1, SGMS2, PTDSS1Golgi apparatusOne of 2 routes

• glycineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 13 routes

• (R)-methylmalonyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 8 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 25 moreendoplasmic reticulum, extracellular space

• butanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 12 routes

• glutaryl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 18 routes

• itaconyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 18 routes

• tetradecanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 15 routes

• octanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 20 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 moreendoplasmic reticulum, extracellular space

• phytanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 25 moreendoplasmic reticulum, cytosolOne of 21 routes

• prostaglandin H2Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space, cytosolOne of 5 routes