UCH proteinases

DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin, and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains.

Summary from Reactome (R-HSA-5689603), read 2026-09-23.