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Proteins/UNIPROT:O00238
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction..
Function from UniProtKB (O00238), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 rows
106 statements
106 statements · 5 reference databases · Subject: BMPR1B · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
3 names
Resolves to: BMPR1B
Rhea RHEA:18673CC BY 4.0Reference data
L-threonyl-[receptor-protein]+ATP(4-)O-phospho-L-threonyl-[receptor-protein]+ADP(3-)+hydron
Catalysed by BMPR1B or ACVR2A or BMPR1A or ACVR1B or TGFBR1 or ACVRL1 or TGFBR2 or ACVR1 or ACVR2B or BMPR2 or AMHR2 or ACVR1C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44880CC BY 4.0Reference data