Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P14314

PRKCSH

Protein·UNIPROT:P14314

Open in the graph

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)..

Function from UniProtKB (P14314), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

polycystic liver disease 1 has a germline basis in PRKCSHDiseaseGenCC HGNC:9411|MONDO:0008265Inferred only

Statements

52 statements

52 statements · 2 reference databases · Subject: PRKCSH · Sources: Hetionet, Reactome

Search this listOrder

PRKCSH covaries with CACYBPProteinHetionet hetionet:covaries:27101-5589Inferred only
RALGDS covaries with PRKCSHProteinHetionet hetionet:covaries:5589-5900Inferred only
PRKCSH covaries with SART1ProteinHetionet hetionet:covaries:5589-9092Inferred only
STMN3 covaries with PRKCSHProteinHetionet hetionet:covaries:50861-5589Inferred only
ARL4D interacts with PRKCSHProteinHetionet hetionet:interacts:379-5589Inferred only
CANX interacts with PRKCSHProteinHetionet hetionet:interacts:5589-821Inferred only
EGR1 interacts with PRKCSHProteinHetionet hetionet:interacts:1958-5589Inferred only
PRKCSH interacts with GANABProteinHetionet hetionet:interacts:23193-5589Inferred only
PRKCSH interacts with GBA3ProteinHetionet hetionet:interacts:5589-57733Inferred only
PRKCSH interacts with GET4ProteinHetionet hetionet:interacts:51608-5589Inferred only
PRKCSH interacts with IKBKEProteinHetionet hetionet:interacts:5589-9641Inferred only
PRKCSH interacts with PRKCZProteinHetionet hetionet:interacts:5589-5590Inferred only

Show the remaining 40

PRKCSH interacts with PTPRCProteinHetionet hetionet:interacts:5589-5788Inferred only
PRKCSH interacts with RGS2ProteinHetionet hetionet:interacts:5589-5997Inferred only
PRKCSH interacts with RPS6ProteinHetionet hetionet:interacts:5589-6194Inferred only
PRKCSH interacts with TRAF6ProteinHetionet hetionet:interacts:5589-7189Inferred only
PRKCSH interacts with UBCProteinHetionet hetionet:interacts:5589-7316Inferred only
PRKCSH interacts with VDRProteinHetionet hetionet:interacts:5589-7421Inferred only
PRKCSH participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
PRKCSH participates in Advanced glycosylation endproduct receptor signalingPathwayReactome R-HSA-879415Inferred only
PRKCSH participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
PRKCSH participates in Calnexin/calreticulin cyclePathwayReactome R-HSA-901042Inferred only
PRKCSH participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
PRKCSH participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
PRKCSH participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
PRKCSH participates in DiseasePathwayReactome R-HSA-1643685Inferred only
PRKCSH participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PRKCSH participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
PRKCSH participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
PRKCSH participates in Late SARS-CoV-2 Infection EventsPathwayReactome R-HSA-9772573Inferred only
PRKCSH participates in Maturation of spike proteinPathwayReactome R-HSA-9694548Inferred only
PRKCSH participates in Maturation of spike proteinPathwayReactome R-HSA-9683686Inferred only
PRKCSH participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PRKCSH participates in N-glycan trimming in the ER and Calnexin/Calreticulin cyclePathwayReactome R-HSA-532668Inferred only
PRKCSH participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
PRKCSH participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
PRKCSH participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
PRKCSH participates in Regulation of CDH1 posttranslational processing and trafficking to plasma membranePathwayReactome R-HSA-9768727Inferred only
PRKCSH participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
PRKCSH participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
PRKCSH participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
PRKCSH participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
PRKCSH participates in SARS-CoV-1 InfectionPathwayReactome R-HSA-9678108Inferred only
PRKCSH participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
PRKCSH participates in Translation of Structural ProteinsPathwayReactome R-HSA-9683701Inferred only
PRKCSH participates in Translation of Structural ProteinsPathwayReactome R-HSA-9694635Inferred only
PRKCSH participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
DIABLO decreases the expression of PRKCSHProteinHetionet hetionet:regulates:56616-5589Inferred only
PGBD1 decreases the expression of PRKCSHProteinHetionet hetionet:regulates:84547-5589Inferred only
PHF21B decreases the expression of PRKCSHProteinHetionet hetionet:regulates:112885-5589Inferred only
PPP1R14B decreases the expression of PRKCSHProteinHetionet hetionet:regulates:26472-5589Inferred only
SMAD7 decreases the expression of PRKCSHProteinHetionet hetionet:regulates:4092-5589Inferred only

Other names

6 names

Resolves to: PRKCSH

Also called: 80K-H proteinG19P1Glucosidase II subunit betakinase C substrate 60.1 kDa protein heavy chainPKCSHProtein kinase C substrate 60.1 kDa protein heavy chain

← Every protein Find it in the graph →