Pathway
Signaling by Hedgehog
Hedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and Angers, 2011). Hh signaling also contributes to stem cell homeostasis in adult tissues. Downregulation of Hh signaling can lead to neonatal abnormalities, while upregulation of signaling is associated with the development of various cancers.
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Hh signaling is switched between 'off' and an 'on' states to differentially regulate an intracellular signaling cascade that targets the Gli transcription factors. In the absence of Hh ligand, cytosolic Gli proteins are cleaved to yield a truncated form that translocates into the nucleus and represses target gene transcription. Binding of Hh to the Patched (PTC) receptor on the cell surface stabilizes the Gli proteins in their full-length transcriptional activator form, stimulating Hh-dependent gene expression (reviewed in Hui and Angers, 2011; Briscoe and Therond, 2013).
REACT:R-HSA-5358351Reactome
What the reference databases state
Statements
135 statements
135 statements · 1 reference database · Subject: Signaling by Hedgehog · Sources: Reactome
- ADAM17 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY10 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY4 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY5 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY8 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADCY9 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ADRM1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
Show the remaining 123
- ARRB1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ARRB2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- BOC participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- BTRC participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- CDC73 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- CDON participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- CSNK1A1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- CUL1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- CUL3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DERL2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DHH participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DISP2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DRC4 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DYNC2H1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- DZIP1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- EFCAB7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ERLEC1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- EVC participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- EVC2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- FUZ participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GAS1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GLI1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GLI2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GLI3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GPC5 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GPR161 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GRK2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- GSK3B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- HHAT participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- HHIP participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT122 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT140 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT172 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT52 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT57 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IFT88 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IHH participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- INTU participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- IQCE participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ITCH participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- KIF3A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- KIF7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- MKS1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- NOTUM participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- NUMB participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- OFD1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- OS9 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- P4HB participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKACA participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKACB participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKACG participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKAR1A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKAR1B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKAR2A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PRKAR2B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA4 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA5 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMA7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB4 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB5 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMB7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC4 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC5 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMC6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD11 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD12 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD13 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD14 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD7 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PSMD8 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- PTCH1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- RBX1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- RPGRIP1L participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- RPS27A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SCUBE2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SEL1L participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SEM1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SHH participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SKP1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SMO participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SMURF1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SMURF2 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SPOP participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SPOPL participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SUFU participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- SYVN1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TTC21B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA1A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA1B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA1C participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA3C participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA3D participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBA4A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB1 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB2A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB2B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB4A participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB4B participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TUBB6 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- TULP3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- UBA52 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- UBB participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- UBC participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- ULK3 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- VCP participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- WDR19 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only
- WDR35 participates in Signaling by HedgehogProteinReactome R-HSA-5358351Inferred only