(2S)-2-phospholactate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

79 compounds within 3 steps: 1 in 1, 12 in 2, 66 in 3

Three steps

D-serineReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. D-serine = pyruvate + NH4(+)
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
(R)-lactic acidReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by PGP, LDHA, LDHB, LDHC and 3 morecytosol
(S)-lactic acidReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (S)-Lactate:NAD+ oxidoreductase
Catalysed by PGP, LDHA, LDHB, LDHC and 2 moremitochondrial matrixOne of 8 routes
2-iminopropanoateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
phosphoenolpyruvic acidReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. pyruvate kinase (dTDP)
Catalysed by PGP, LDHA, LDHB, LDHC and 4 morecytosol
N-acetyl-beta-neuraminic acidReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by PGP, LDHA, LDHB, LDHC and 3 morecytosol
malonaldehydeReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
3. thromboxane A synthase (12(S)-HHT)
Catalysed by PGP, SLCO2A1, TBXAS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
a 3-acylpyruvateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
15-oxoprostaglandin E2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)
Catalysed by PGP, SLCO2A1, HPGDinner side of the membrane, outer side of the membraneOne of 2 routes
15-oxoprostaglandin E1Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
3. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Catalysed by PGP, SLCO2A1, CBR3, CBR1 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes
prostaglandin I2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
3. prostaglandin I2 synthase (prostaglandin H2)
Catalysed by PGP, SLCO2A1, PTGISinner side of the membrane, outer side of the membrane, endoplasmic reticulumOne of 2 routes
15-oxoprostaglandin D2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
3. 15-dehydro-prostaglandin D2 reduction
Catalysed by PGP, SLCO2A1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
thromboxane A2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
3. thromboxane A synthase (prostaglandin H2)
Catalysed by PGP, SLCO2A1, TBXAS1inner side of the membrane, outer side of the membrane, endoplasmic reticulumOne of 4 routes
2-oxo-3-sulfanylpropanoateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
2-methyl-3-oxopropanoateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
L-methionineReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by PGP, LDHA, LDHB, LDHC and 4 more
glutathioneReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
3. urate(out) + glutathione(in) = urate(in) + glutathione(out)
Catalysed by PGP, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane
L-alanineReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by PGP, LDHA, LDHB, LDHC and 3 moremitochondrial matrixOne of 18 routes
L-phenylalanineReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
Catalysed by PGP, CNDP2
(3S)-citramalyl-CoAReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
5-amino-2-oxopentanoateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by PGP, LDHA, LDHB, LDHC and 3 more
CHEBI:730073Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
3. Peroxidase
Catalysed by PGP, SLC22A12, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes
11beta-prostaglandin F2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)
Catalysed by PGP, SLCO2A1, AKR1C3, AKR1C2inner side of the membrane, outer side of the membrane
(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
Catalysed by PGP, SLCO2A1, TBXAS1, CYP2S1 and 1 moreinner side of the membrane, outer side of the membrane
prostaglandin H1Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
3. prostaglandin-E synthase (prostaglandin E1)
Catalysed by PGP, SLCO2A1, PTGES, PTGES3 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
19-hydroxyprostaglandin H2Reach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PGP, SLCO2A1, CYP4F8inner side of the membrane, outer side of the membrane
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by PGP, LDHA, LDHB, LDHC and 5 moremitochondrial matrix