15-oxoprostaglandin D2

Three steps

• thromboxane A2Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. prostaglandin-D synthase (prostaglandin D2)
  3. thromboxane A synthase (prostaglandin H2)

  Catalysed by HPGDS, PTGDS, TBXAS1cytosol, endoplasmic reticulumOne of 2 routes

• leukotriene A4Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO2A1, GLO1, GLOD4cytosol, extracellular spaceOne of 2 routes

• S-formylglutathioneReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 morecytosol, extracellular space

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

• leukotriene C4Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• glutathione disulfideReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO2A1, SQORcytosol, extracellular space, mitochondrial matrix

• dopamineReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLCO2A1, PGPcytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. aldo-keto reductase (prostaglandin D2)
  3. carbonyl reductase (NADPH) (prostaglandin F2alpha)

  Catalysed by AKR1C3, CBR3, CBR1, DHRS4cytosolOne of 10 routes

• L-cysteinylglycineReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 morecytosol, extracellular spaceOne of 4 routes

• (R)-noradrenalineReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. prostaglandin-D synthase (prostaglandin D2)
  3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

  Catalysed by HPGDS, PTGDS, TBXAS1, CYP2S1 and 1 morecytosol, endoplasmic reticulum

• thromboxane B2Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• 19-hydroxyprostaglandin H2Reach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. prostaglandin-D synthase (prostaglandin D2)
  3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by HPGDS, PTGDS, CYP4F8cytosol, endoplasmic reticulum

• taurochenodeoxycholateReach from here →
  1. 15-dehydro-prostaglandin D2 reduction
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3cytosol, extracellular spaceOne of 4 routes