glycine

Three steps

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 5 moreperoxisome, Golgi apparatusOne of 2 routes

• a triacyl-sn-glycerolReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 7 moreperoxisome, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 4 moreperoxisome, Golgi apparatus

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL3, AGPAT3, AGPAT5

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL3, LPCAT1

• 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 3-oxoeicosasphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)

  Catalysed by GLYATL3, CERS6, CERS5

• a 2,3-saturated acyl-CoAReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• 3-oxoeicosanoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 11 moreperoxisome, cytosolOne of 2 routes

• N-docosanoylsphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosol

• N-eicosanoylsphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosol

• N-(octadecanoyl)-sphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 10 moreperoxisome, cytosol

• N-hexadecanoylsphinganineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)

  Catalysed by GLYATL3, CERS6, CERS5, CERS2

• N-(tetradecanoyl)-sphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxohexadecasphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxotetradecasphinganineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• (R)-adrenalineReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by GSS, SLCO1A2, SLCO1B3, PNMTcytosol, extracellular spaceOne of 2 routes

• 3-oxooctadecanoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 3 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
  3. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 3',3'-cGAMPReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by SHMT1, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by BAAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosol, endoplasmic reticulumOne of 2 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosolOne of 2 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosol

• 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL3, LPCAT1

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 more

• 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL3, LCLAT1, LPCAT1, LPGAT1

• 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL3, LPGAT1

• 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL3, LPGAT1

• 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL3, LPGAT1

• 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by GLYATL3, LCLAT1

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 more

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL3, AGPAT2

• N-dodecanoylsphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 2 moreperoxisome, Golgi apparatus

• N-tetradecanoylsphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatus

• N-hexadecanoylsphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by BAAT, ASAH1, ACER2, ACER1 and 5 moreperoxisome, Golgi apparatusOne of 3 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 3 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 2 routes

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL3, PRDX6, LPCAT3, LPCAT1

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL3, LPGAT1