phosphoenolpyruvic acid

Three steps

• 3-hydroxy-L-kynurenineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by PKM, PKLR, AGXT2, KYNUcytosol, mitochondrial matrix

• L-homocysteineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

• S-methyl-L-methionineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

• N-acetylputrescineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol, mitochondrial matrixOne of 7 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by PKM, PKLR, AGXT2, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 1D-myo-inositol 3-phosphateReach from here →
  1. dATP:pyruvate 2-O-phosphotransferase
  2. dATP:D-glucose 6-phosphotransferase
  3. 1D-myo-inositol-3-phosphate lyase (isomerizing)

  Catalysed by PKM, PKLR, HK1, HK2 and 3 morecytosol

• kynurenateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by PKM, PKLR, MPST, AADATcytosolOne of 2 routes

• 7,8-dihydroneopterin 3'-triphosphateReach from here →
  1. pyruvate kinase (dTDP)
  2. dTTP + H2O = thymidine + triphosphate + H(+)
  3. 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)

  Catalysed by PKM, PKLR, SAMHD1, PTScytosol

• N(8)-acetylspermidineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (S)-3-amino-2-methylpropanoateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by PKM, PKLR, AGXT2, ABATcytosol, mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

• L-methionine (R)-S-oxideReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 3 morecytosol

• thiamine triphosphateReach from here →
  1. dATP:pyruvate 2-O-phosphotransferase
  2. Antiport of thiamine-diphosphate and dATP
  3. ATP:thiamine-diphosphate phosphotransferase

  Catalysed by PKM, PKLR, SLC25A19, TPK1cytosol, mitochondrial matrix

• (2S)-2-phospholactateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by PKM, PKLR, LDHA, LDHB and 4 morecytosolOne of 2 routes

• L-prolineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by PKM, PKLR, AGXT2, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by PKM, PKLR, LDHA, LDHB and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• dCTPReach from here →
  1. dATP:pyruvate 2-O-phosphotransferase
  2. cytidine/uridine monophosphate kinase (dADP)
  3. ATP:dCDP phosphotransferase

  Catalysed by PKM, PKLR, CMPK1, NME4 and 5 morecytosolOne of 11 routes

• dUTPReach from here →
  1. dGTP:pyruvate 2-O-phosphotransferase
  2. thymidine kinase (deoxyuridine)
  3. dUTP + H2O = dUMP + diphosphate + H(+)

  Catalysed by PKM, PKLR, DUTcytosol

• L-cysteinylglycineReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PKM, PKLR, AGXT2, GGTLC3 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• Mo-molybdopterinReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PKM, PKLR, AGXT2, MOCOScytosol, mitochondrial matrix

• (2S)-2-aminobutanoateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by PKM, PKLR, AGXT2cytosol, mitochondrial matrixOne of 6 routes

• 2-iminobutanoateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by PKM, PKLR, AGXT2, RIDAcytosol

• 2-aminoprop-2-enoateReach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by PKM, PKLR, SRRcytosol

• thromboxane B2Reach from here →
  1. GTP:pyruvate 2-O-phosphotransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by PKM, PKLR, LDHA, LDHB and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →
  1. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  2. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  3. aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

  Catalysed by ENO1, ENO2, ENO3, ENO4 and 1 morecytosol