tetra-mu3-sulfido-tetrairon(2+)

Three steps

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. lipoyl synthase
  2. transport of methionine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• tryptamineReach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. lipoyl synthase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• (S)-2-hydroxyglutarateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• formaldehydeReach from here →
  1. lipoyl synthase
  2. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

• CHEBI:16856Reach from here →
  1. lipoyl synthase
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. cystine to cysteine conversion

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 3 routes

• glyoxylic acidReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. lipoyl synthase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxalic acidReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-glutamic 5-semialdehydeReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• dehydroascorbic acidReach from here →
  1. lipoyl synthase
  2. Fe(II):oxygen oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix, extracellular space

• COReach from here →
  1. lipoyl synthase
  2. Ferrochelatase, Mitochondrial
  3. Heme Oxygenase 1

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 2 routes

• anilineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrixOne of 4 routes

• sulfiteReach from here →
  1. lipoyl synthase
  2. Sulfide:glutathione,quinone oxidoreductase
  3. Persulfide dioxygenase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrixOne of 10 routes

• CHEBI:17380Reach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. lipoyl synthase
  2. transport of methionine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosol

• 5-aminolevulinic acidReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, extracellular space, cytosol

• indole-3-pyruvateReach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 3,3'-diiodo-L-thyronineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrixOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. Steryl-Sulfatase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, Golgi apparatusOne of 4 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, cytosol

• glycine betaineReach from here →
  1. lipoyl synthase
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. lipoyl synthase
  2. transport of histidine and methionine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• urateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• 5-hydroxy-L-tryptophanReach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• methylarsonous acidReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• 4-methyl-2-oxopentanoateReach from here →
  1. lipoyl synthase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• fumaric acidReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and thiosulfate (cytosol to mitochondria)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 4 routes

• thiocyanateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrixOne of 3 routes

• CHEBI:18095Reach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. Transport of Hydroxy-Proline

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. lipoyl synthase
  2. transport of chloride and methionine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• arsenic triglutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrixOne of 3 routes

• 2-phenylethylamineReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. lipoyl synthase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• ophthalmateReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix