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Reach

(9Z,12Z)-octadecadienoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

348 compounds within 3 steps: 13 in 1, 47 in 2, 288 in 3

Does it reach a compound?

Two steps

1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LCLAT1
1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, LCLAT1
1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, MOGAT2 and 1 more
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
Catalysed by ACSL3, ACSBG2, SLC27A3, AGPAT4
(2E,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
2. (9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
Catalysed by ACSL3, ACSBG2, SLC27A3, ACADL and 2 more
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
2. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by PLA2G6, PNPLA8
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
2. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by ABHD16A
13-oxo-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O
Catalysed by ALOX15, ALOX12, CYP1A1, CYP1A2 and 3 more

Three steps

(S)-carnitineReach from here →
Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 246 routes
CHEBI:1307929Reach from here →

Page 2 of 7

Catalysed by ACSL3, ACSBG2, SLC27A3, SOAT2 and 3 more

endoplasmic reticulum, lysosome

One of 2 routes

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)

Catalysed by PTGS2, AIFM1, PYROXD1, MOCS1

S-octanoyl-4'-phosphopantetheineReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
Beta Oxidation of Fatty Acid
octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACADM and 4 moremitochondrial matrix

an acyl-4'-phosphopantetheineReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by ACSL3, ACSBG2, SLC27A3, NUDT19 and 2 morecytosol

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

all-trans-3,4-didehydroretinolReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O

Catalysed by PTGS2, RETSAT, CYP27C1

all-trans-4-hydroxyretinolReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Catalysed by PTGS2, RETSAT, CYP27C1

prostaglandin H3Reach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
A + NADH + H(+) = AH2 + NAD(+)
2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PTGS2, AIFM1, PYROXD1

2-hydroxyoctanoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
Beta Oxidation of Fatty Acid
octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

Catalysed by ACSL3, ACSBG2, SLC27A3, ACADM and 2 moremitochondrial matrix

all-trans-retinyl tetradecanoateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

Catalysed by PTGS2, RETSAT, AWAT2

N-octanoylglycineReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
Beta Oxidation of Fatty Acid
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACADM and 2 moremitochondrial matrix

1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by ACSL3, ACSBG2, SLC27A3, LPCAT3 and 3 more

(7Z)-octadecenoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 4 routes

CHEBI:15345Reach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 5 morecytosolOne of 2 routes

cholineReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Acetyl-CoA:choline O-acetyltransferase

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 5 morecytosol, nucleus

pyruvateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
L-cysteine hydrogen-sulfide-lyase (deaminating

Catalysed by PTGS2, MOCOS, CTHcytosolOne of 6 routes

CHEBI:15380Reach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 6 morecytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Production of Tiglylcarnitine

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 6 morecytosolOne of 2 routes

isobutyryl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 5 morecytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Arachidonate:CoA ligase (AMP-forming)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 12 routes

CHEBI:15519Reach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
propanoyl-CoA C-acyltransferase

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Palmitate:CoA ligase (AMP-forming)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 10 morecytosolOne of 12 routes

oleoyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Transport of octadecenoyl-CoA into Mitochondrial Matrix

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 12 routes

phenylacetyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Phenylacetate:CoA ligase

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 4 morecytosolOne of 3 routes

propionyl-CoAReach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
Propanoate:CoA ligase (AMP-forming)

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 7 morecytosolOne of 43 routes

(S)-malateReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
(R)-malate + A = oxaloacetate + AH2
transport of malate and OAA (cytosol to mitochondria)

Catalysed by PTGS2, D2HGDHmitochondrial matrix, cytosolOne of 5 routes

L-leucineReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
transport of cysteine and leucine (cytosol to extracellular)

Catalysed by PTGS2, MOCOS, SLC7A9, SLC3A1extracellular space, cytosolOne of 3 routes

15(S)-HPETEReach from here →

(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Glutathione: 15-HPETE oxidoreductase

Catalysed by ALOX15, ALOX12, GPX1, GSTA1 and 8 morecytosol

CHEBI:15650Reach from here →

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
(6Z,9Z)-octadecadienoyl-CoA hydrolase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by ACSL3, ACSBG2, SLC27A3, ACOT7 and 36 morecytosolOne of 2 routes

all-trans-3-hydroxyretinolReach from here →

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Catalysed by PTGS2, RETSAT, CYP27C1