a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

249 compounds within 3 steps: 6 in 1, 43 in 2, 200 in 3

Three steps

AReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by GBA1, GBA3, GBA2, CH25H
an acyl-4'-phosphopantetheineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 6 moreGolgi apparatus
cholesterol sulfateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by GBA1, GBA3, GBA2, SULT2B1 and 1 more
(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA1, GBA3, GBA2, LCAT
a 3-hydroxyacyl derivative of bacterial toxinReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
3. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
Catalysed by ASAH1, AOAH
a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a fatty acyl-CoA = a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA
Catalysed by ASAH1, ACSL3, PIGW
an N-(fatty acyl)-glycineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by ASAH1, ACSL3, GLYATL2
cholesteryl (7Z)-octadecenoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA
Catalysed by GBA1, GBA3, GBA2, SOAT1
(7Z)-octadecenoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
pyruvateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. dATP:pyruvate 2-O-phosphotransferase
Catalysed by GBA1, GBA3, GBA2, HK1 and 5 morecytosol
arachidonoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
palmitoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
oleoyl-CoAReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA pool formation and breakdown
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
hexadecanoic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
1-acylglycerone 3-phosphateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. Acyl-CoA:glycerone-phosphate O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 4 moreGolgi apparatus, cytosol
keto-D-fructose 6-phosphateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ATP:D-glucose 6-phosphotransferase
3. D-glucose-6-phosphate aldose-ketose-isomerase
Catalysed by GBA1, GBA3, GBA2, HK1 and 5 morecytosol
thioredoxin dithiolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
Catalysed by GBA1, GBA3, GBA2, HK1 and 8 morecytosol, mitochondrial matrixOne of 2 routes
phosphatidylethanolamineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 8 moreGolgi apparatus, cytosolOne of 2 routes
CHEBI:16039Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ITP:D-glucose 6-phosphotransferase
3. ATP:IDP phosphotransferase
Catalysed by GBA1, GBA3, GBA2, HK1 and 8 morecytosolOne of 3 routes
1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 moreGolgi apparatus, cytosolOne of 2 routes
CHEBI:16284Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. ATP:dADP phosphotransferase
Catalysed by GBA1, GBA3, GBA2, HK1 and 8 morecytosolOne of 16 routes
11-cis-retinolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
3. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
Catalysed by ASAH1, RPE65cytosolOne of 2 routes
phosphatidic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 12 moreGolgi apparatus, mitochondrial matrixOne of 9 routes
CHEBI:16436Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. ceramide cholinephosphotransferase (CDP-choline)
Catalysed by GBA1, GBA3, GBA2, SGMS1 and 1 moreGolgi apparatus, endoplasmic reticulum
alpha,alpha-trehaloseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. D-glucose 1-epimerase
3. alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
Catalysed by GBA1, GBA3, GBA2, GALM and 1 morecytosol
pregnenoloneReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
Catalysed by GBA1, GBA3, GBA2, CYP11A1
galactitolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
3. galactitol:NADP+ 1-oxidoreductase
Catalysed by B4GALT5, B4GALT6, LCT, GLB1 and 3 morelysosome, cytosol
psychosineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 3 moreGolgi apparatus, cytosol
1-acyl-sn-glycerol 3-phosphateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 moreGolgi apparatus, mitochondrial matrixOne of 7 routes
a cholesterol esterReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. an acyl-CoA + cholesterol = a cholesterol ester + CoA
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 5 moreGolgi apparatusOne of 2 routes
a neolactoside nLc4Cer(d18:1(4E))Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)
3. beta-1,4-galactosyltransferase (lc3Cer)
Catalysed by B4GALT5, B4GALT6, B3GNT5, B4GALT3 and 3 morecytosolOne of 2 routes
CHEBI:17202Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ITP:D-glucose 6-phosphotransferase
3. IDP phosphohydrolase
Catalysed by GBA1, GBA3, GBA2, HK1 and 11 morecytosol, extracellular space
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)
3. N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase (lc3Cer)
Catalysed by B4GALT5, B4GALT6, B3GNT5, B3GALT2 and 2 morecytosolOne of 3 routes
all-trans-retinolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
3. carboxylesterase (retinyl-ester)
Catalysed by ASAH1, RPE65, CES2, RBP4 and 18 morecytosolOne of 2 routes
linoleic acidReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
a 2-acylglycerolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
Catalysed by GBA1, GBA3, GBA2, SGMS1 and 4 moreGolgi apparatus
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 7 moreGolgi apparatus, cytosol
7alpha-hydroxycholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA1, GBA3, GBA2, CYP7A1
26-hydroxycholesterolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA1, GBA3, GBA2, CYP3A4
glycerolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
Catalysed by ASAH1, LIPE
a triacylglycerolReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. acyl-CoA:sphingosine N-acyltransferase
3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Catalysed by GBA1, GBA3, GBA2, ASAH1 and 8 moreGolgi apparatus, cytosolOne of 2 routes
alpha-D-glucoseReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. D-glucose 1-epimerase
3. alpha-D-glucose = beta-D-glucose
Catalysed by GBA1, GBA3, GBA2, GALMcytosol
4-methylpentanalReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
Catalysed by GBA1, GBA3, GBA2, CYP11A1
dTDPReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. nucleoside-diphosphate kinase (dADP)
Catalysed by GBA1, GBA3, GBA2, HK1 and 9 morecytosolOne of 3 routes
CHEBI:18132Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. ceramide:phosphatidylcholine cholinephosphotransferase
3. Sphingomyelin cholinephosphohydrolase
Catalysed by GBA1, GBA3, GBA2, SGMS1 and 6 moreGolgi apparatus, cytosolOne of 4 routes
a globoside Gb4Cer (d18:1(4E))Reach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
2. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
3. globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (globotriaosylceramide)
Catalysed by B4GALT5, B4GALT6, A4GALTcytosolOne of 4 routes
dodecanoateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. N-Acylsphingosine amidohydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA1, GBA3, GBA2, ASAH1lysosome, extracellular spaceOne of 12 routes
D-gluconateReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)
3. D-glucono-1,5-lactone + H2O = D-gluconate + H(+)
Catalysed by GBA1, GBA3, GBA2, H6PD and 1 more
cholesteryl 3-beta-D-galactosideReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine
Catalysed by GBA1, GBA3, GBA2, UGT8One of 3 routes
cholesteryl 3-beta-D-xylosideReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine
Catalysed by GBA1, GBA3, GBA2One of 3 routes