5,6,7,8-tetrahydrofolic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

455 compounds within 3 steps: 7 in 1, 86 in 2, 362 in 3

Three steps

Mo-molybdopterinReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of alanine and glycine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A10 and 1 morecytosol, extracellular space
(2E)-octadecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine O-Palmitoyltransferase
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 8 routes
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by SHMT1, AADAT, HOGA1cytosol
(R)-noradrenalineReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and noradrenaline (cytosol to extracellular)
Catalysed by SHMT1, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 7 routes
heptadecanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
nonadecanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 3 routes
dodecanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Activation of dodecanedioic acid
Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 4 routes
decanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Sebacoylcarnitine
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 4 routes
octanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Suberylcarnitine
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 4 routes
hexanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisome
(13Z)-eicosenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by SHMT1, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SHMT1, BAAT, CRAT, CROTcytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by SHMT1, BAAT, ACAA1, HSD17B4 and 2 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Hexadecanedioylcarnitine
Catalysed by SHMT1, BAAT, CPT1A, CPT1C and 1 morecytosol, peroxisomeOne of 2 routes
pristanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. fatty-acid-CoA ligase
Catalysed by SHMT1, BAAT, SLC27A2cytosol, peroxisomeOne of 2 routes
undecanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by SHMT1, BAAT, ACSM4, ACSM1 and 4 morecytosol, peroxisomeOne of 3 routes
a fatty acyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by SHMT1, GLYATL2cytosol
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by SHMT1, GSS, GPX1, GPX4cytosol
ursodeoxycholateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by SHMT1, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by SHMT1, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of cysteine and glycine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A8 and 1 morecytosol, extracellular space
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SHMT1, GSS, GPX1, GPX2 and 1 morecytosol
(5Z)-tetradecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by SHMT1, BAAT, ACADM, ECHS1 and 2 morecytosol, peroxisome, mitochondrial matrix
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by SHMT1, BAAT, HADHA, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. transport of glutamine and glycine (cytosol to extracellular)
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by SHMT1, SLC7A5, GLYATL1B, GLYATL1cytosol, extracellular space
(7Z)-hexadecenoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 8 routes
3-methylmalateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by SHMT1, AADAT, CLYBLcytosol
tricosanoyl-CoAReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by SHMT1, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 4 routes
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SHMT1, GSS, PTGES, MGST3 and 4 morecytosol