N(omega),N('omega)-dimethyl-L-arginine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

536 compounds within 3 steps: 3 in 1, 95 in 2, 438 in 3

Three steps

2-hydroxybutyric acidReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes
3-methyl-2-oxobutanoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and valine (cytosol to extracellular)
3. L-Valine:2-oxoglutarate aminotransferase
Catalysed by AGXT2, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes
2-phenylpropan-2-olReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, CLIC2, GPX1 and 2 more
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)
Catalysed by AGXT2, MOCOS, MOCS1
a hydroxy polyunsaturated fatty acidReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
Catalysed by AGXT2, GSS, GPX1, GPX2 and 1 more
AReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and cysteine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by AGXT2, SLC7A5, MOCOSextracellular space, cytosolOne of 72 routes
tauroursodeoxycholateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
Catalysed by AGXT2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes
N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine
Catalysed by AGXT2, GLYATL2, ALOX15, ALOX12
N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine
Catalysed by AGXT2, GLYATL2, ALOX15B, ALOX15 and 1 more
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2One of 2 routes
(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. glutathione transferase (GSH)
Catalysed by AGXT2, GSS, PTGES, MGST3 and 19 morecytosolOne of 5 routes
prostaglandin E3Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin E3 (cytosol to extracellular)
Catalysed by AGXT2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin H3Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
prostaglandin A2Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin A2 (cytosol to extracellular)
Catalysed by AGXT2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
prostaglandin B1Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin B1 (cytosol to extracellular)
Catalysed by AGXT2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
leukotriene F4Reach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and leukotriene F4 (cytosol to extracellular)
Catalysed by AGXT2, GSScytosol, extracellular spaceOne of 4 routes
prostaglandin A2-S-(R)-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione
Catalysed by AGXT2, GSS, GSTA1, GSTM1
prostaglandin A2-S-(S)-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione
Catalysed by AGXT2, GSS, GSTP1, GSTM1
prostaglandin J2-S-(R)-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione
Catalysed by AGXT2, GSS, GSTA1, GSTP1 and 1 more
prostaglandin J2-S-(S)-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione
Catalysed by AGXT2, GSS, GSTP1, GSTM1
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
2,4-dinitrophenyl-S-glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. solute carrier organic anion transporter (glycocholate)
Catalysed by AGXT2, BAAT, SLCO1A2, SLCO1B3peroxisome, extracellular space, cytosolOne of 11 routes
N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and phenylalanine (cytosol to extracellular)
3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
Catalysed by AGXT2, SLC7A5, PM20D1extracellular space, cytosol
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and phenylalanine (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by AGXT2, SLC7A5, PM20D1extracellular space, cytosol
N-(9Z-octadecenoyl)-L-leucineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and leucine (cytosol to extracellular)
3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
Catalysed by AGXT2, SLC7A5, PM20D1extracellular space, cytosol
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by AGXT2, MOCOS, PTGS1, PTGS2
acetoacetateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
3. transport of acetoacetate and pyruvate (cytosol to mitochondria)
Catalysed by AGXT2mitochondrial matrix, cytosolOne of 4 routes
(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
Catalysed by AGXT2, GSS, GSTM4, LTC4S
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by AGXT2, MOCOS, PTGS2
N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. gamma-glutamyltransferase (alanine)
3. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
Catalysed by AGXT2, GGTLC3, GGT1, GGT5 and 4 morecytosol
S-methyl glutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
Catalysed by AGXT2, GSS, MMACHC
N-octanoyl-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
Catalysed by AGXT2, PAMOne of 2 routes
N-decanoyl-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
Catalysed by AGXT2, PAMOne of 2 routes
N-dodecanoyl-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
Catalysed by AGXT2, PAMOne of 2 routes
N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
Catalysed by AGXT2, PAMOne of 2 routes
N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate
Catalysed by AGXT2, PAMOne of 2 routes
N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
Catalysed by AGXT2, PAM
D-histidineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and ornithine (cytosol to extracellular)
3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
Catalysed by AGXT2, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
L-homoarginineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and arginine (cytosol to extracellular)
3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
Catalysed by AGXT2, SLC7A6, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes
L-homocarnosineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and histidine (cytosol to extracellular)
3. Formation of homocarnosine
Catalysed by AGXT2, SLC7A6, CARNS1extracellular space, cytosol
2,3-didehydrophenylalanineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
Catalysed by AGXT2, DPEP1
S-adenosylglutathioneReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
Catalysed by AGXT2, GSS, MMACHC
N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
3. N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)
Catalysed by AGXT2, GART
2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and glutamine (cytosol to extracellular)
3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)
Catalysed by AGXT2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol