1)-Cer(d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

75 compounds within 3 steps: 8 in 1, 16 in 2, 51 in 3

Three steps

fatty acidReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. N-Acylsphingosine amidohydrolase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 4 morelysosome, cytosol
a fatty aldehydeReach from here →
1. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
2. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)
Catalysed by A4GALT, ASAH1, ALDH3A2cytosol
alpha-lactoseReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 6 morelysosome, cytosol, Golgi apparatus
D-glucopyranose 6-phosphateReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. ATP:D-glucose 6-phosphotransferase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 8 morelysosome, cytosolOne of 5 routes
an N-acylsphing-4-enine 1-phosphateReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)
Catalysed by LCT, GLB1, GLB1L, TMPPE and 5 morelysosome, cytosol
sphing-4-enineReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 7 morelysosome, cytosol, Golgi apparatusOne of 4 routes
CMP-N-acetyl-beta-neuraminateReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM3)
3. CTP:N-acetylneuraminate cytidylyltransferase
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morecytosol, nucleusOne of 2 routes
an acyl-CoAReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 7 morelysosome, cytosol, Golgi apparatusOne of 2 routes
alpha-D-glucose 1-phosphateReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. galactokinase (galactose)
3. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
Catalysed by LCT, GLB1, GLB1L, TMPPE and 3 morelysosome, cytosol
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →
1. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)
2. beta-1,4-galactosyltransferase (lc3Cer)
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by B3GNT5, B4GALT3, B4GALT4, B4GALT2 and 2 morecytosolOne of 2 routes
D-glucose 6-phosphateReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
Catalysed by LCT, GLB1, GLB1L, TMPPE and 4 morelysosome, cytosolOne of 2 routes
a globoside GalGb4Cer (d18:1(4E))Reach from here →
1. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
2. globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (globotriaosylceramide)
3. a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + UDP + H(+)
Catalysed by A4GALT, B3GALT5cytosol
an all-trans-retinyl esterReach from here →
1. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
2. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
3. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
Catalysed by A4GALT, ASAH1, RPE65cytosol
UDP-alpha-D-galactoseReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. galactokinase (galactose)
3. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
Catalysed by LCT, GLB1, GLB1L, TMPPE and 3 morelysosome, cytosol
CHEBI:67119Reach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. galactokinase (galactose)
3. UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
Catalysed by LCT, GLB1, GLB1L, TMPPE and 3 morelysosome, cytosolOne of 2 routes
an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by LCT, GLB1, GLB1L, TMPPE and 6 morelysosome, cytosol
a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)
2. beta-1,4-galactosyltransferase (lc3Cer)
3. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by B3GNT5, B4GALT3, B4GALT4, B4GALT2 and 2 morecytosol
a 1,3-diacyl-sn-glycerolReach from here →
1. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
2. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
Catalysed by A4GALT, ASAH1, ABHD11cytosol
a fatty acyl-CoAReach from here →
1. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
2. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
Catalysed by A4GALT, ASAH1, ACSL3cytosol
a ganglioside GM1 (d18:1(4E))Reach from here →
1. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
2. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
3. beta-1,3-galactosyltransferase (GM2)
Catalysed by B4GALNT1, ST6GALNAC2, ST3GAL5, B3GALT4cytosolOne of 3 routes
a ganglioside GT3 (d18:1(4E))Reach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
3. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST3GAL5, ST8SIA1, ST8SIA5cytosolOne of 3 routes
a ganglioside GD2 (d18:1(4E))Reach from here →
1. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
2. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by B4GALNT1, ST6GALNAC2, ST3GAL5, ST8SIA1cytosolOne of 4 routes
a ganglioside GM1b (d18:1(4E))Reach from here →
1. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
2. a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + UDP + H(+)
3. a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)
Catalysed by B4GALNT1, B3GALT4, ST3GAL1, ST3GAL4 and 1 morecytosol
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by LCT, GLB1, GLB1L, TMPPE and 4 morelysosome, cytosol
1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
1. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
2. D-Glucosyl-N-acylsphingosine glucohydrolase
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by LCT, GLB1, GLB1L, TMPPE and 5 morelysosome, cytosol