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(2E,6E)-farnesyl diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

83 compounds within 3 steps: 10 in 1, 6 in 2, 67 in 3

Does it reach a compound?

One step

isopentenyl diphosphateReach from here →
1. isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
Catalysed by GGPS1, FDPS
squaleneReach from here →
1. Squalene Synthase
Catalysed by FDFT1endoplasmic reticulumOne of 3 routes
presqualene diphosphateReach from here →
1. farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
Catalysed by FDFT1cytosolOne of 3 routes
(2E)-geranyl diphosphateReach from here →
1. isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
Catalysed by GGPS1, FDPS
all-trans-nonaprenyl diphosphateReach from here →
1. 6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate
Catalysed by PDSS1, PDSS2
(2E,6E,10E)-geranylgeranyl diphosphateReach from here →
1. Farnesyltranstransferase
Catalysed by GGPS1cytosolOne of 2 routes
Fe(II)-heme oReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Catalysed by COX10mitochondrial matrixOne of 4 routes
all-trans-decaprenyl diphosphateReach from here →
1. decaprenyl diphosphate synthase (farnesyl-PP)
Catalysed by PDSS1, PDSS2cytosolOne of 2 routes
(2E,6E)-farnesyl triphosphateReach from here →
1. (2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP
Catalysed by NME1
(2E,6E)-farnesyl phosphateReach from here →
1. (2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)
Catalysed by NUDT18, PLPP6, NUDT15

Two steps

(S)-2,3-epoxysqualeneReach from here →
1. Squalene Synthase
2. squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Catalysed by FDFT1, SQLEendoplasmic reticulum, cytosolOne of 3 routes
(2E,6E)-farnesolReach from here →
1. (2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)
2. (2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate
Catalysed by NUDT18, PLPP6, NUDT15
AH2Reach from here →

Three steps

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →
Catalysed by COX10, COX15, MOCS1mitochondrial matrix
AReach from here →
Catalysed by

Page 1 of 2

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

Catalysed by COX10, COX15mitochondrial matrix

heme bReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate

Catalysed by COX10mitochondrial matrix

Fe(II)-heme aReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

Catalysed by COX10, COX15mitochondrial matrix

4-hydroxy-3-(all-trans-decaprenyl)benzoateReach from here →

decaprenyl diphosphate synthase (farnesyl-PP)
solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase

Catalysed by PDSS1, PDSS2, COQ2cytosol, mitochondrial matrixOne of 6 routes

mitochondrial matrix

One of 70 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

prostaglandin H3Reach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

13-hydroxy-(9Z,11E)-octadecadienoateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

9-hydroxy-(10E,12Z)-octadecadienoateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by COX10, COX15, PTGS1, PTGS2mitochondrial matrix

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

Catalysed by COX10, COX15, PTGS2mitochondrial matrix

(2E,6E)-farnesalReach from here →

(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)
(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate
(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + NADPH + H(+)

Catalysed by NUDT18, PLPP6, NUDT15, AKR1B15

cob(II)alaminReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

Catalysed by COX10, COX15, MTRRmitochondrial matrix

iodideReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 22 routes

nitric oxideReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

Catalysed by COX10, COX15, SUOXmitochondrial matrix

lanosterolReach from here →

Squalene Synthase
squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
(S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)

Catalysed by FDFT1, SQLE, LSSendoplasmic reticulum, cytosolOne of 3 routes

3'-deoxy-3',4'-didehydro-CTPReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Catalysed by COX10, COX15, RSAD2mitochondrial matrix

(S)-2-hydroxyglutarateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

Catalysed by COX10, COX15, L2HGDHmitochondrial matrix

COReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
Heme Oxygenase 1

Catalysed by COX10, HMOX1, HMOX2mitochondrial matrix, cytosolOne of 2 routes

5'-deoxyadenosineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Catalysed by COX10, COX15, CDK5RAP1mitochondrial matrixOne of 4 routes

3,3',5'-triiodo-L-thyronine sulfateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

Catalysed by COX10, COX15, DIO1mitochondrial matrix

3,3'-diiodo-L-thyronineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

3,3'-diiodo-L-thyronine sulfateReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

Catalysed by COX10, COX15, DIO1mitochondrial matrixOne of 2 routes

3',5'-diiodo-L-thyronineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

Catalysed by COX10, COX15, DIO3mitochondrial matrix

3-iodothyronamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

3-iodo-L-thyronineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

3'-iodo-L-thyronineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

L-thyronineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

Catalysed by COX10, COX15, DIO3mitochondrial matrix

thyronamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

Catalysed by COX10, COX15, DIO3mitochondrial matrix

3'-iodothyronamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

3,3'-diiodothyronamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

3',5'-diiodothyronamineReach from here →

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

Catalysed by COX10, COX15, DIO3mitochondrial matrix