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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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presqualene diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

3 compounds within 3 steps: 1 in 1, 1 in 2, 1 in 3

Does it reach a compound?

One step

squaleneReach from here →
1. presqualene-diphosphate diphosphate-lyase (reducing, squalene-forming)
Catalysed by FDFT1cytosolOne of 4 routes

Two steps

(S)-2,3-epoxysqualeneReach from here →
1. presqualene-diphosphate diphosphate-lyase (reducing, squalene-forming)
2. squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Catalysed by FDFT1, SQLEcytosolOne of 3 routes

Three steps

lanosterolReach from here →
Catalysed by FDFT1, SQLE, LSScytosolOne of 3 routes