glyoxylic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

860 compounds within 3 steps: 6 in 1, 226 in 2, 628 in 3

Two steps

(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
(2S)-2-aminobutanoateReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by AGXT, AGXT2mitochondrial matrix
nonadecanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Activation of dodecanedioic acid
Catalysed by CLYBLmitochondrial matrix, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Production of Sebacoylcarnitine
Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Production of Suberylcarnitine
Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by CLYBLmitochondrial matrix, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by CLYBL, CRAT, CROTmitochondrial matrix, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by CLYBL, ACAA1, HSD17B4, EHHADH and 1 moremitochondrial matrix, peroxisome
hexadecanedioyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Production of Hexadecanedioylcarnitine
Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. fatty-acid-CoA ligase
Catalysed by CLYBL, SLC27A2mitochondrial matrix, cytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by CLYBL, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 3 routes
glycodeoxycholateReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. Glycodeoxycholate amidohydrolase
Catalysed by AGXT, AGXT2mitochondrial matrix, cytosolOne of 2 routes
(5Z)-tetradecenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by CLYBL, ACADM, ECHS1, ACAA2 and 1 moremitochondrial matrix
N-tetradecanoylglycineReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by AGXT, AGXT2, GLYATL2mitochondrial matrix
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by CLYBL, HADHA, ACAA2, HADHBmitochondrial matrix
N-eicosanoylglycinateReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by AGXT, AGXT2, BAATmitochondrial matrix
N-docosanoylglycineReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by AGXT, AGXT2, BAATmitochondrial matrix
N-hexacosanoylglycineReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by AGXT, AGXT2, BAATmitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. L-Alanine:glyoxylate aminotransferase
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by AGXT, AGXT2, PDHA1, PDHB and 1 moremitochondrial matrix

Three steps

beta-carbolineReach from here →
Catalysed by AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosol
(S)-3-hydroxybutanoateReach from here →
Catalysed by