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Reach

CHEBI:16856

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

729 compounds within 3 steps: 51 in 1, 174 in 2, 504 in 3

Does it reach a compound?

One step

taurochenodeoxycholateReach from here →
1. solute carrier organic anion transporter (GSH)
Catalysed by SLCO1A2, SLC7A9, SLCO1B3extracellular space, cytosolOne of 2 routes

Two steps

(S)-carnitineReach from here →
1. transport of arachidonate and GSH (cytosol to extracellular)
2. Utilized Transport
No catalyst recordedextracellular space, cytosol, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
1. transport of GSH and leukotriene E4 (cytosol to extracellular)
2. N-acetyl-LTE4 to leukotriene E4 conversion
Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosolOne of 4 routes
(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Page 2 of 15

Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

AReach from here →

transport of GSH and thyroxine (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3extracellular space, cytosolOne of 8 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP3A4, CYP2C8 and 4 moreextracellular space, cytosol

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP3A4, CYP2C8 and 4 moreextracellular space, cytosol

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C8, CYP2C9, CYP2C19, CYP2J2 and 1 moreextracellular space, cytosol

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP2C8, CYP2D6, CYP2C9 and 3 moreextracellular space, cytosol

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C9, CYP2J2extracellular space, cytosol

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP2D6, CYP2C9, CYP2C19 and 2 moreextracellular space, cytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1extracellular space, cytosol

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4, CYP2C9extracellular space, cytosol

prostaglandin J2Reach from here →

transport of GSH and prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by SLCO2A1extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by SLCO2A1extracellular space, cytosolOne of 4 routes

dopamine 3-O-sulfateReach from here →

transport of dopamine and GSH (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SLCO1A2, SLCO1B3, SULT1B1, SULT1A3 and 2 moreextracellular space, cytosol

dopamine 4-O-sulfateReach from here →

transport of dopamine and GSH (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A1extracellular space, cytosolOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

transport of GSH and prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by SLCO2A1, GSTA1, GSTM1extracellular space, cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

transport of GSH and prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by SLCO2A1, GSTP1, GSTM1extracellular space, cytosol

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by ALOX15extracellular space, cytosol

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by ALOX15extracellular space, cytosol

2,4-dinitrophenyl-S-glutathioneReach from here →

leukotriene C4 synthase (GSH)
transport of leukotriene C4 (cytosol to extracellular)

Catalysed by LTC4S, SLCO1B1cytosol, extracellular spaceOne of 76 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by PM20D1extracellular space, cytosol

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosolOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosolOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C9extracellular space, cytosol

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosol

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

L-cystine-bis-glycineReach from here →

glutathione gamma-glutamylaminopeptidase
2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

No catalyst recordedextracellular space, cytosolOne of 2 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

Catalysed by FAAH, PM20D1extracellular space, cytosol

(15S)-15-hydroperoxy-prostaglandin E2Reach from here →

transport of GSH and prostaglandin G2 (cytosol to extracellular)
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

Catalysed by SLCO2A1, PTGESextracellular space, cytosol

cholineReach from here →

transport of acetylcholine and GSH (cytosol to extracellular)
Acetylcholine aectylhydrolase

Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 5 routes

pyruvateReach from here →

cystine to cysteine conversion
L-cysteine hydrogen-sulfide-lyase (deaminating

Catalysed by CTHcytosolOne of 2 routes

arachidonoyl-CoAReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
Arachidonate:CoA ligase (AMP-forming)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 3 routes

CHEBI:15519Reach from here →

solute carrier organic anion transporter (cholate)
Cholate:CoA ligase (AMP-forming)

Catalysed by SLCO1A2, SLCO1B3, SLC27A2, SLC27A5extracellular space, cytosol, endoplasmic reticulum

L-leucineReach from here →

cystine to cysteine conversion
transport of cysteine and leucine (cytosol to extracellular)

Catalysed by SLC7A9, SLC3A1cytosol, extracellular spaceOne of 3 routes

12(S)-HPETEReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
arachidonate:oxygen 12-oxidoreductase

Catalysed by ALOX12extracellular space, cytosolOne of 4 routes

15(S)-HPETEReach from here →

Glutathione: 5-HPETE oxidoreductase
Glutathione: 15-HPETE oxidoreductase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 6 routes

5(S)-HPETEReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
Arachidonate:oxygen 5-oxidoreductase

Catalysed by ALOX5extracellular space, cytosol

CHEBI:15699Reach from here →

cystine to cysteine conversion
transport of cysteine and homoserine (cytosol to extracellular)

Catalysed by SLC7A5cytosol, extracellular spaceOne of 3 routes

formateReach from here →

alcohol dehydrogenase (formaldehyde)
S-formylglutathione + H2O = formate + glutathione + H(+)

Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 morecytosol

CHEBI:15971Reach from here →

cystine to cysteine conversion
transport of cysteine and histidine (cytosol to extracellular)

Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

(R)-lactateReach from here →

(R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Catalysed by GLO1, GLOD4, HAGHcytosol

sulfateReach from here →

transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
steroid sulfatase (sulfoglycolithocholate)

Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosol

L-cystineReach from here →

Glutathione: 5-HPETE oxidoreductase
cystine to cysteine conversion

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 5 routes

L-citrullineReach from here →

cystine to cysteine conversion
transport of citrulline and cysteine (cytosol to extracellular)

Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

iodideReach from here →

transport of GSH and thyroxine (cytosol to extracellular)
3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2extracellular space, cytosolOne of 9 routes