CHEBI:16436

Three steps

• all-trans-retinolReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Lecithin Retinol Acyltransferase
  3. carboxylesterase (retinyl-ester)

  Catalysed by CHPT1, CEPT1, LRAT, CES2 and 19 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• a 2-acylglycerolReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2 and 3 morecytosol, Golgi apparatus

• a monoacylglycerolReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. 1,2-diacyl-sn-glycerol acylhydrolase

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2 and 15 morecytosol, Golgi apparatus, extracellular spaceOne of 9 routes

• AH2Reach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylserine synthase (PC-LD pool)
  3. choline + A = betaine aldehyde + AH2

  Catalysed by CHPT1, CEPT1, PTDSS1, CHDHcytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS2, LRATendoplasmic reticulumOne of 2 routes

• 4-methylumbelliferyl acetateReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 6 morecytosol

• a diacylglycerolReach from here →
  1. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by CHPT1, CEPT1, TMEM68, DDHD2 and 18 morecytosolOne of 2 routes

• dodecanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by UGCGendoplasmic reticulum, cytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by UGT8endoplasmic reticulumOne of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by GBA1, GBA3endoplasmic reticulumOne of 2 routes

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by UGCGendoplasmic reticulumOne of 2 routes

• docosanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• octadecanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• alpha-linolenic acidReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• elaidic acidReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol, endoplasmic reticulum

• chlorine(.)Reach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylserine synthase (PC-LD pool)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by CHPT1, CEPT1, PTDSS1, SLC5A7cytosol, extracellular space

• formic acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 6 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. transport of acetate and propanoate (cytosol to extracellular)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 7 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. transport of acetate and butyrate (cytosol to extracellular)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 7 morecytosol, extracellular spaceOne of 2 routes

• tetradecanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 13 routes

• hexacosanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. N-acylsphingosine amidohydrolase

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 21 morecytosol, endoplasmic reticulumOne of 2 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatus

• eicosanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• an acylcholineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylserine synthase (PC-LD pool)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by CHPT1, CEPT1, PTDSS1, BCHEcytosol

• a fatty aldehydeReach from here →
  1. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by CHPT1, CEPT1, PLA2G6, PLA2G4A and 5 morecytosol

• a sterol esterReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, LCATendoplasmic reticulum

• cholesteryl hexadecanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes

• (S)-lactic acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. transport of acetate and L-lactate (cytosol to extracellular)

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 9 morecytosol, extracellular spaceOne of 2 routes

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol

• a 1,3-diacylglycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 5 routes

• a 1,2-diacylglycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by SGMS1, SGMS2, PTDSS1endoplasmic reticulum

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol

• an N-acylsphing-4-enine 1-phosphateReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by AGK, CERKendoplasmic reticulum

• sphing-4-enineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2endoplasmic reticulum, Golgi apparatusOne of 4 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SGMS1, SGMS2, LPGAT1endoplasmic reticulumOne of 12 routes

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  3. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by CHPT1, CEPT1, PLA2G6, PLA2G4A and 6 morecytosol