CHEBI:16039

Three steps

• sedoheptuloseReach from here →
  1. ITP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. ATP:sedoheptulose 7-phosphate

  Catalysed by HK1, HK2, HK3, HKDC1 and 2 morecytosolOne of 2 routes

• D-xyluloseReach from here →
  1. ITP:D-fructose 6-phosphotransferase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. ATP:D-xylulose 5-phosphotransferase

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosol

• methylglyoxalReach from here →
  1. ITP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. glycerone-phosphate phosphate-lyase (methylglyoxal-forming)

  Catalysed by HK1, HK2, HK3, HKDC1 and 1 morecytosol

• 2'-deoxyguanosineReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. inosine 5'-monophosphate phosphohydrolase
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by ITPA, ACP3, NT5E, NT5C2 and 4 morecytosol

• myo-inositolReach from here →
  1. ITP:D-glucose 6-phosphotransferase
  2. 1D-myo-inositol-3-phosphate lyase (isomerizing)
  3. 1D-myo-inositol 3-phosphate phosphohydrolase

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosolOne of 2 routes

• anilineReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by HK1, HK2, GNPNAT1, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by HK1, HK2, GNPNAT1cytosolOne of 2 routes

• hypoxanthineReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. inosine 5'-monophosphate phosphohydrolase
  3. inosine:phosphate alpha-D-ribosyltransferase

  Catalysed by ITPA, ACP3, NT5E, NT5C2 and 5 morecytosolOne of 2 routes

• L-cysteineReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by HK1, HK2, GNPNAT1, NAGScytosol, mitochondrial matrix

• cytidineReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. inosine 5'-monophosphate phosphohydrolase
  3. inosine + CMP = cytidine + IMP

  Catalysed by ITPA, ACP3, NT5E, NT5C2 and 4 morecytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by HK1, HK2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrix

• lactoseReach from here →
  1. ITP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, endoplasmic reticulum

• CHEBI:17797Reach from here →
  1. ITP:D-fructose 6-phosphotransferase
  2. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
  3. transketolase (D-xylulose-5-phosphate)

  Catalysed by HK1, HK2, HK3, HKDC1 and 4 morecytosolOne of 2 routes

• D-glucitolReach from here →
  1. ITP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. Aldehyde Reductase

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• CHEBI:17927Reach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by HK1, HK2, GNPNAT1cytosol

• fumaric acidReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. IMP:L-aspartate ligase (GDP-forming)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by ITPA, ADSS2, ADSS1, ADSL and 1 morecytosolOne of 2 routes

• xanthosineReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. IMP:NAD+ oxidoreductase
  3. xanthosine 5'-phosphate phosphohydrolase

  Catalysed by ITPA, IMPDH2, IMPDH1, ACP3 and 7 morecytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by HK1, HK2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by HK1, HK2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by HK1, HK2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by HK1, HK2, GNPNAT1, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by HK1, HK2, GNPNAT1, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by HK1, HK2, GNPNAT1, ACSM4 and 5 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by HK1, HK2, GNPNAT1, ACAA1 and 2 morecytosol, peroxisomeOne of 7 routes

• 2'-deoxyinosineReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. inosine 5'-monophosphate phosphohydrolase
  3. dIMP + inosine = 2'-deoxyinosine + IMP

  Catalysed by ITPA, ACP3, NT5E, NT5C2 and 4 morecytosol

• L-aspartateReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. IMP:L-aspartate ligase (GDP-forming)
  3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

  Catalysed by ITPA, ADSS2, ADSS1cytosol

• acetateReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by HK1, HK2, GNPNAT1, CEMP1 and 1 morecytosolOne of 2 routes

• beta-D-fructose 1,6-bisphosphateReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate

  Catalysed by HK1, HK2, GNPDA1, GNPDA2 and 2 morecytosolOne of 2 routes

• D-ribose 1-phosphateReach from here →
  1. Inosine 5'-triphosphate pyrophosphohydrolase
  2. inosine 5'-monophosphate phosphohydrolase
  3. inosine:phosphate alpha-D-ribosyltransferase

  Catalysed by ITPA, ACP3, NT5E, NT5C2 and 5 morecytosol

• alpha-lactoseReach from here →
  1. ITP:D-glucose 6-phosphotransferase
  2. D-Glucose-6-phosphate phosphohydrolase
  3. UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase

  Catalysed by HK1, HK2, HK3, HKDC1 and 6 morecytosol, endoplasmic reticulum, Golgi apparatus

• taurineReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by HK1, HK2, GNPNAT1, BAATcytosolOne of 2 routes

• glycineReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by HK1, HK2, GNPNAT1, GLYAT and 2 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by HK1, HK2, GNPNAT1, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by HK1, HK2, GNPNAT1cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by HK1, HK2, GNPNAT1, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by HK1, HK2, GNPNAT1cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by HK1, HK2, GNPNAT1, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by HK1, HK2, GNPNAT1, ACSM4 and 5 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by HK1, HK2, GNPNAT1, CPT1A and 2 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by HK1, HK2, GNPNAT1, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by HK1, HK2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by HK1, HK2, GNPNAT1, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. ITP:D-glucosamine 6-phosphotransferase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by HK1, HK2, GNPNAT1cytosolOne of 5 routes