L-homoarginine

Three steps

• L-tyrosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC25A2, GATM, AADATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• N(1)-acetylspermidineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

  Catalysed by SLC25A2, ODC1, PAOXinner side of the membrane, outer side of the membrane, cytosol

• trans-4-hydroxy-L-prolineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC25A2, SLC7A6, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• histamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, HDCinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-2-aminopentanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane

• L-2-aminohexanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane

• S-sulfanyl-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC25A2, SLC7A6, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC25A2, SLC7A6, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 5-phospho-beta-D-ribosylamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC25A2, SLC7A6, PPATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC25A2, SLC7A6, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC25A2, SLC7A6, MSRAinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC25A2, SLC7A6, MSRB3, MSRB1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• methylamineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
  3. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

  Catalysed by SLC25A29, DDAH1inner side of the membrane, outer side of the membrane

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC25A2, SLC7A6, PPCSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• 3-iodo-L-tyrosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC25A2, SLC7A6, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC25A2, SLC7A6, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-benzoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLC25A2, SLC7A6, CDO1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC25A2, SLC7A6, GGTLC3, GGT1 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SLC25A2, GATM, AGXT2inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• thio-Mo-molybdopterinReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC25A2, SLC7A6, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycodeoxycholateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-eicosanoylglycinateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• N-docosanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• N-hexacosanoylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC25A2, SLC7A6, GLYATL1B, GLYATL1inner side of the membrane, outer side of the membrane, extracellular space, cytosol