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Proteins/UNIPROT:Q16829
Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity)..
Function from UniProtKB (Q16829), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
94 statements
94 statements · 4 reference databases · Subject: DUSP7 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 reactions
2 names
Resolves to: DUSP7
O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20629CC BY 4.0Reference data
O-phospho-L-threonyl-[protein]+waterL-threonyl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 59 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47004CC BY 4.0Reference data