Proteins/UNIPROT:Q9NQ76

MEPE

ProteinUNIPROT:Q9NQ76

Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation..

Function from UniProtKB (Q9NQ76), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

nonsyndromic genetic hearing loss has a germline basis in MEPEDiseaseGenCC HGNC:13361|MONDO:0019497Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: MEPE · Sources: Hetionet, Reactome, WikiPathways

Order

MEPE covaries with BRCA1ProteinHetionet hetionet:covaries:56955-672Inferred only
MEPE covaries with LRIF1ProteinHetionet hetionet:covaries:55791-56955Inferred only
MEPE covaries with NLRP14ProteinHetionet hetionet:covaries:338323-56955Inferred only
PAGE4 covaries with MEPEProteinHetionet hetionet:covaries:56955-9506Inferred only
PCDHB6 covaries with MEPEProteinHetionet hetionet:covaries:56130-56955Inferred only
MEPE covaries with SPATA31H1ProteinHetionet hetionet:covaries:56955-84226Inferred only
MEPE covaries with TATDN2ProteinHetionet hetionet:covaries:56955-9797Inferred only
MEPE covaries with ZFP69BProteinHetionet hetionet:covaries:56955-65243Inferred only
ZNF318 covaries with MEPEProteinHetionet hetionet:covaries:24149-56955Inferred only
ABL1 interacts with MEPEProteinHetionet hetionet:interacts:25-56955Inferred only
CHEK1 interacts with MEPEProteinHetionet hetionet:interacts:1111-56955Inferred only
CRK interacts with MEPEProteinHetionet hetionet:interacts:1398-56955Inferred only

Show the remaining 12

FYN interacts with MEPEProteinHetionet hetionet:interacts:2534-56955Inferred only
GRB2 interacts with MEPEProteinHetionet hetionet:interacts:2885-56955Inferred only
NCK1 interacts with MEPEProteinHetionet hetionet:interacts:4690-56955Inferred only
PIK3R1 interacts with MEPEProteinHetionet hetionet:interacts:5295-56955Inferred only
PLCG1 interacts with MEPEProteinHetionet hetionet:interacts:5335-56955Inferred only
SRC interacts with MEPEProteinHetionet hetionet:interacts:56955-6714Inferred only
MEPE participates in 8p23 1 copy number variation syndromePathwayWikiPathways WP5346Inferred only
MEPE participates in Clock controlled autophagy in bone metabolismPathwayWikiPathways WP5205Inferred only
MEPE participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MEPE participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
MEPE participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
MEPE participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only

Other names

3 names

Resolves to: MEPE

Also called: OF45Osteoblast/osteocyte factor 45Osteoregulin

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