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Proteins/UNIPROT:O00418
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced..
Function from UniProtKB (O00418), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 4 reference databases · Subject: EEF2K · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
[translation elongation factor 2]+ATP(4-)[translation elongation factor 2]-phosphate+ADP(3-)+hydron
Catalysed by EEF2K
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21436CC BY 4.0Reference data
3 names
Resolves to: EEF2K