Proteins/UNIPROT:Q5T9L3

WLS

ProteinUNIPROT:Q5T9L3

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity)..

Function from UniProtKB (Q5T9L3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Zaki syndrome has a germline basis in WLSDiseaseGenCC HGNC:30238|MONDO:0859209Inferred only

Statements

19 statements

19 statements · 3 reference databases · Subject: WLS · Sources: gene ontology, Hetionet, Reactome

Order

OPRM1 interacts with WLSProteinHetionet hetionet:interacts:4988-79971Inferred only
UBC interacts with WLSProteinHetionet hetionet:interacts:7316-79971Inferred only
WLS participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
WLS participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
WLS participates in WNT ligand biogenesis and traffickingPathwayReactome R-HSA-3238698Inferred only
WLS regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q5T9L3|GO:0043123Inferred only
WLS regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q5T9L3|GO:0090263Inferred only
WLS regulates positive regulation of Wnt protein secretionBiological processgene ontology Q5T9L3|GO:0061357Inferred only
WLS regulates positive regulation of Wnt signaling pathwayBiological processgene ontology Q5T9L3|GO:0030177Inferred only
HLA-DMB increases the expression of WLSProteinHetionet hetionet:regulates:3109-79971Inferred only
ITPR1 increases the expression of WLSProteinHetionet hetionet:regulates:3708-79971Inferred only
NPTN increases the expression of WLSProteinHetionet hetionet:regulates:27020-79971Inferred only

Show the remaining 7

RNF125 increases the expression of WLSProteinHetionet hetionet:regulates:54941-79971Inferred only
SMARCA4 decreases the expression of WLSProteinHetionet hetionet:regulates:6597-79971Inferred only
SOX4 decreases the expression of WLSProteinHetionet hetionet:regulates:6659-79971Inferred only
STK25 increases the expression of WLSProteinHetionet hetionet:regulates:10494-79971Inferred only
SWAP70 increases the expression of WLSProteinHetionet hetionet:regulates:23075-79971Inferred only
TXNL4B increases the expression of WLSProteinHetionet hetionet:regulates:54957-79971Inferred only
VRK2 increases the expression of WLSProteinHetionet hetionet:regulates:7444-79971Inferred only

Other names

7 names

Resolves to: WLS

Also called: C1orf139evenness interrupted homologEVIGPR177Integral membrane protein GPR177Protein evenness interrupted homologPutative NF-kappa-B-activating protein 373

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